Armodafinil Improves Creativity Performance on the Remote Associates Test in Night Workers with Shift Work Disorder

Details

• Personal Author:
  Drake C ; Gable M ; Gumenyuk V ; Howard R ; Roth T
• Description:
  Introduction: Armodafinil is a wakefulness promoting agent used for the treatment of excessive sleepiness (ES) in individuals with Shift Work Disorder (SWD). In the present study, we determined the effect of armodafinil on creativity as measured by the Remote Associates Test (RAT), which was developed as an associative evaluation of the process of creative thinking. We further attempted to determine if this improvement was related to changes in alertness as measured by the multiple sleep latency test (MSLT). Methods: Participants were 10 night workers (age: 44.2 +/- 9. 78 years, 8F) that complained of ES (>/=10 on the Epworth Sleepiness Scale (ESS); mean= 13.8 +/- 2.9), meeting ICSD-2 criteria for SWD, and having no other sleep or medical disorders. During each 12 hour study (2130- 0930), subjects were kept awake in a moderately lit room (500 lux in the angle of gaze) and out of bed except for MSLT (0130, 0330, 0530, and 0730). Wakefulness was monitored using polysomnography (PSG). Armodafinil (150 mg) or placebo was administered (2345) in a randomized, double-blind, crossover design. At 0400, subjects were read instructions and given 40 minutes to complete the RAT. Results: Armodafinil significantly improved both RAT and MSLT scores: there was a 26% improvement in RAT score with armodafinil administration compared to placebo (8.2 +/- 4.6 vs. 10.3 +/- 5.6, p=0.03), and a 5 minute increase in MSLT score (4.8 +/- 2.6min vs. 9.9 +/- 4.2min, p=0.005). A repeated measures ANCOVA controlling for MSLT score difference found that armodafinil's effect on RAT score remains significant [F(1,7)=8.28, p=0.02], suggesting that RAT score improvement is, at least in part, independent of armodafinil's effect on alertness. Conclusion: Armodafinil improves creativity as measured by the RAT in night workers with SWD marked by ES. Importantly, covarying for alertness improvement did not negate the effect on creativity. [Description provided by NIOSH]
• Subjects:
  Mental Health Occupational Health Safety Sleep Sleep Initiation And Maintenance Disorders
• Keywords:
  Psychological Effects Shift Workers Sleep Deprivation Sleep Disorders Work Schedules
• ISSN:
  0161-8105
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  36
• NIOSHTIC Number:
  nn:20055590
• Citation:
  Sleep 2013 Jun; 36(Abstract Suppl):A182
• Federal Fiscal Year:
  2013
• Performing Organization:
  Henry Ford Health System, Detroit, Michigan
• Peer Reviewed:
  False
• Start Date:
  20110901
• Source Full Name:
  Sleep
• Supplement:
  Abstract Supplement
• End Date:
  20140831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:82c61f44192e486f33139268dc9e9e9cee00e00375b7b56729750166256e6b7e2548ba1d149cef8053f441e0244848d33d7f5c43476791db94a78879850b83df
• Download URL:
  https://stacks.cdc.gov/view/cdc/213408/cdc_213408_DS1.pdf
• File Type:
  [PDF - 865.69 KB ]