Healthy Lifestyle During the Midlife Is Prospectively Associated with Less Subclinical Carotid Atherosclerosis: The Study of Women’s Health Across the Nation

Details

• Personal Author:
  Baylin A ; Chae CU ; Crawford SL ; Derby CA ; El Khoudary SR ; Elliott MR ; Harlow SD ; Hood MM ; Huang M-H ; Jackson EA ; Janssen I ; Karvonen-Gutierrez CA ; Sternfeld B ; Wang D
• Description:
  Background: Measures of subclinical atherosclerosis are predictors of future cardiovascular outcomes as well as of physical and cognitive functioning. The menopausal transition is associated with accelerated progression of atherosclerosis in women. The prospective association between a healthy lifestyle during the midlife and subclinical atherosclerosis is unclear. Methods and Results: Self-reported data on smoking, diet, and physical activity from 1143 women in the Study of Women's Health Across the Nation were used to construct a 10-year average Healthy Lifestyle Score (HLS) during the midlife. Markers of subclinical atherosclerosis were measured 14 years after baseline and included common carotid artery intima-media thickness (CCA-IMT), adventitial diameter (CCA-AD), and carotid plaque. The associations of average HLS with CCA-IMT and CCA-AD were estimated using linear models; the association of average HLS with carotid plaque was estimated using cumulative logit models. Average HLS was associated with smaller CCA-IMT and CCA-AD in the fully adjusted models (P=0.0031 and <0.001, respectively). Compared with participants in the lowest HLS level, those in the highest level had 0.024 mm smaller CCA-IMT (95% confidence interval: -0.048, 0.000), which equals 17% of the SD of CCA-IMT, and 0.16 mm smaller CCA-AD (95% confidence interval: -0.27, -0.04), which equals 24% of the SD of CCA-AD. Among the 3 components of the HLS, abstinence from smoking had the strongest association with subclinical atherosclerosis. Conclusions: Healthy lifestyle during the menopausal transition is associated with less subclinical atherosclerosis, highlighting the growing recognition that the midlife is a critical window for cardiovascular prevention in women. Correction: J Am Heart Assoc 2018 Dec; 7(23):e010405. J Am Heart Assoc 2019 Apr; 8(7):1.On page 1, in the author byline, the degree for the 6th author, Michelle M. Hood, was incorrectly listed as MPH. It has now been corrected to MS. The authors regret the error. [Description provided by NIOSH]
• Subjects:
  Age Factors Cardiovascular Diseases Cardiovascular System Diet Occupational Health Safety Smokers Women
• Keywords:
  Age Factors Author Keywords: Atherosclerosis Cardiovascular Disease Disease Prevention Lifestyle Physical Exercise Risk Factors Smoking
• ISSN:
  2047-9980
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Alabama ; California ; Illinois ; Massachusetts ; Michigan ; New York ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  7
• Issue:
  23
• NIOSHTIC Number:
  nn:20055566
• Citation:
  J Am Heart Assoc 2018 Dec; 7(23):e010405
• Contact Point Address:
  Ana Baylin, MD, DrPH, 1858 SPH I, 1415 Washington Heights, Ann Arbor, MI 48109-2029
• Email:
  abaylin@umich.edu
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of the American Heart Association
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1586ccfdf4d00b22820473210ccbab5b83c238d31ea13ed0ec3b46a181f3e6cd38e36b87bb3c352042fdc603e89a9d48aa7f8f43eb5947fc1897488dabaa0f30
• Download URL:
  https://stacks.cdc.gov/view/cdc/213391/cdc_213391_DS1.pdf
• File Type:
  [PDF - 486.15 KB ]