Age at Onset of Metabolic Syndrome Among Women with and Without Polycystic Ovary Syndrome-Like Status

Details

• Personal Author:
  Harlow SD ; Karvonen-Gutierrez CA ; McConnell D ; Nan B ; Peng Q ; Randolph JF Jr.
• Description:
  Context: Women with polycystic ovary syndrome (PCOS) have a higher prevalence of metabolic syndrome (MetS), but whether they develop MetS earlier than women without PCOS is unknown. Understanding the impact of PCOS on the timing of MetS onset is important for screening and clinical care in this population. Design: Women with PCOS-like status (PCOSp) were identified from participants of the Michigan Bone Health and Metabolism Study based upon history of irregular menstrual cycles, high free-androgen index, and high levels of antimüllerian hormone. MetS was defined according to the Adult Treatment Panel III criteria. Age at MetS onset was compared between women with and without PCOSp using an accelerated failure time model adjusted for baseline education, lifestyle factors, and midlife body weight. Results: Among the 496 women in the analysis, 11.7% (n = 58) were determined to have PCOSp. Over a mean follow-up of 11 years, 20 women with PCOSp and 136 women without PCOSp developed MetS. After adjusting for smoking, education, and physical activity, women with PCOSp developed MetS at an age 14.4% (95% CI -22.7, -5.2) younger than women without PCOSp. The magnitude of the association was attenuated to 5.4% in models additionally adjusted for body mass index (95% CI -12.4, 2.1). Because a typical study participant without PCOSp developed MetS at 51.5 years old, 5.4% translates to almost 3 years earlier onset of MetS for a comparable woman with PCOSp. Conclusions: Women with PCOSp develop MetS at a younger age. Earlier screening for MetS in women with PCOS may be warranted. [Description provided by NIOSH]
• Subjects:
  Age Factors Endocrine System Occupational Health Safety Urogenital Diseases Urogenital System Women
• Keywords:
  Age Factors BMI Body Mass Index Endocrine System Disorders Hormones Metabolic Disorders Reproductive System Disorders
• ISSN:
  0021-972X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Michigan ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  104
• Issue:
  5
• NIOSHTIC Number:
  nn:20055565
• Citation:
  J Clin Endocrinol Metab 2019 May; 104(5):1429-1439
• Contact Point Address:
  Qing Peng, MPH, University of Michigan School of Public Health, 1415 Washington Heights, Room 6622 SPH I, Ann Arbor, Michigan 48109-2029
• Email:
  pengq@umich.edu
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Clinical Endocrinology and Metabolism
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:07e71e400f2812ddfb26608497cde9d7ffdb4e363d42e95b82e1246a6e8019db3f0b535f05d03f1635610591bbfc07aa79be56d1eddca46fd64b9c2b65a6591e
• Download URL:
  https://stacks.cdc.gov/view/cdc/213390/cdc_213390_DS1.pdf
• File Type:
  [PDF - 629.52 KB ]