Toxicological Assessment of Dust from Sanding Micronized Copper-Treated Lumber In Vivo

Details

• Personal Author:
  Andrew, Michael E. ; Battelli LA ; Castranova VC ; Fedan, Jeffery S. ; Lee T ; Mandler WK ; Mckinney WG ; Mercer RR ; Orandle MS ; Porter DW ; Qi C ; Qian Y ; Shaffer J ; Sisler JD ; Thomas TA
• Description:
  Micronized copper azole (MCA) is a lumber treatment improve longevity. In this study, the in vivo response to PM2.5 sanding dust generated from MCA-treated lumber was compared to that of untreated yellow pine (UYP) or soluble copper azole-treated (CA-C) lumber to determine if the MCA was more bioactive than CA-C. Mice were exposed to doses (28, 140, or 280 ug/mouse) of UYP, MCA, or CA-C sanding dust using oropharyngeal aspiration. Bronchoalveolar lavage fluid (BALF) lactate dehydrogenase activity was increased at 1 day post-exposure to 280 ug/mouse of MCA and CA-C compared to UYP. BALF polymorphonuclear cells were increased by MCA and CA-C. There were increases in BALF cytokines in MCA and CA-C-exposed groups at 1 day post-exposure. Lung histopathology indicated inflammation with infiltration of neutrophils and macrophages. Pulmonary responses were more severe in MCA and CA-C-exposed groups at 1 day post-exposure. MCA caused more severe inflammatory responses than CA-C at 1 day post-exposure. These findings suggest that the MCA and CA-C sanding dusts are more bioactive than the UYP sanding dust, and, moreover, the MCA sanding dust is more bioactive in comparison to the CA-C sanding dust. No chronic toxic effects were observed among all observed sanding dusts. Corrigendum: The authors have recently become aware of an error in Figure 10 of the manuscript, and request to issue a correction. In Figure 10, panels A and F are identical. This is an error. In the corrected figure, Panel A has been replaced with its correct version. This error and correction have no impact on the remainder of the manuscript, our interpretation of the data, or the conclusions drawn. [Description provided by NIOSH]
• Subjects:
  Dust Forestry Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety Toxicology Wood
• Keywords:
  Author Keywords: Wood Dust Bioactivation Dusts Inflammation In Vivo Study In Vivo Toxicity Lumber Industry Micronized Copper Pulmonary Injury Pulmonary System Pulmonary System Disorders Respiratory System Disorders Treated Wood Treatment Wood Dust Wood Dusts

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• ISSN:
  0304-3894
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Ohio ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  373
• NIOSHTIC Number:
  nn:20055525
• Citation:
  J Hazard Mater 2019 Jul; 373:630-639
• Contact Point Address:
  Yong Qian, NIOSH/HELD/PPRB, 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  yaq2@cdc.gov
• CAS Registry Number:
  Copper (CAS RN 7440-50-8)
• Federal Fiscal Year:
  2019
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Hazardous Materials
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8b027de52fcb30db249f9fd95b38d1c49fe4da8192e683b5a4006e55ebcf59e19a5cae4bd4cda371aa53101c450ea5a171a2c4f253c9ad77cc1a00ba0fec0707
• Download URL:
  https://stacks.cdc.gov/view/cdc/213360/cdc_213360_DS1.pdf
• File Type:
  [PDF - 2.79 MB ]