Receptor for Advanced Glycation End-Products and Environmental Exposure Related Obstructive Airways Disease: A Systematic Review

Details

• Personal Author:
  Caraher EJ ; Crowley G ; Haider SH ; Kim JS ; Kwon S ; Lam R ; Mikhail M ; Nolan A ; Oskuei A ; Riggs J ; Talusan A ; Veerappan A
• Description:
  Background: Our group has identified the receptor for advanced glycation end-products (RAGE) as a predictor of World Trade Center particulate matter associated lung injury. The aim of this systematic review is to assess the relationship between RAGE and obstructive airways disease secondary to environmental exposure. Methods: A comprehensive search using PubMed and Embase was performed on January 5, 2018 utilising keywords focusing on environmental exposure, obstructive airways disease and RAGE and was registered with PROSPERO (CRD42018093834). We included original human research studies in English, focusing on pulmonary end-points associated with RAGE and environmental exposure. Results: A total of 213 studies were identified by the initial search. After removing the duplicates and applying inclusion and exclusion criteria, we screened the titles and abstracts of 61 studies. Finally, 19 full-text articles were included. The exposures discussed in these articles include particulate matter (n=2) and cigarette smoke (n=17). Conclusion: RAGE is a mediator of inflammation associated end-organ dysfunction such as obstructive airways disease. Soluble RAGE, a decoy receptor, may have a protective effect in some pulmonary processes. Overall, RAGE is biologically relevant in environmental exposure associated lung disease. Future investigations should focus on further understanding the role and therapeutic potential of RAGE in particulate matter exposure associated lung disease. [Description provided by NIOSH]
• Subjects:
  Dust Environmental Exposure Lung Diseases Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety September 11 Terrorist Attacks
• Keywords:
  Airway Obstruction Environmental Exposure Lung Disease Particulate Dust World Trade Center WTC
• ISSN:
  1600-0617
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  28
• Issue:
  151
• NIOSHTIC Number:
  nn:20055498
• Citation:
  Eur Respir Rev 2019 Mar; 28(151):180096
• Contact Point Address:
  Anna Nolan, New York University School of Medicine, Dept of Medicine, Division of Pulmonary, Critical Care and Sleep, New Bellevue, 462 1st Avenue, New York, NY 10016, USA
• Email:
  anna.nolan@med.nyu.edu
• Federal Fiscal Year:
  2019
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20170701
• Source Full Name:
  European Respiratory Review
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2800c5a3db7c4c07eb0fbf9bf6447cc87287218db83b32280ee02f3fd9956309ec57117bb99c9fd56497907308fbe8a210e574c6a37d71e94e49483ce270792e
• Download URL:
  https://stacks.cdc.gov/view/cdc/213335/cdc_213335_DS1.pdf
• File Type:
  [PDF - 356.39 KB ]