Evaluation of the Irritable Bowel Syndrome Quality of Life (IBS-QOL) Questionnaire in Diarrheal-Predominant Irritable Bowel Syndrome Patients

Details

• Personal Author:
  Andrae DA ; Covington PS ; Drossman DA ; Patrick DL ; Andrae DA ; Covington PS ; Drossman DA ; Patrick DL
• Description:
  Background: Diarrhea-predominant irritable bowel syndrome (IBS-d) significantly diminishes the health-related quality of life (HRQOL) of patients. Psychological and social impacts are common with many IBS-d patients reporting comorbid depression, anxiety, decreased intimacy, and lost working days. The Irritable Bowel Syndrome Quality of Life (IBS-QOL) questionnaire is a 34-item instrument developed and validated for measurement of HRQOL in non-subtyped IBS patients. The current paper assesses this previously-validated instrument employing data collected from 754 patients who participated in a randomized clinical trial of a novel treatment, eluxadoline, for IBS-d. Methods: Psychometric methods common to HRQOL research were employed to evaluate the IBS-QOL. Many of the historical analyses of the IBS-QOL validations were used. Other techniques that extended the original methods were applied where more appropriate for the current dataset. In IBS-d patients, we analyzed the items and substructure of the IBS-QOL via item reduction, factor structure, internal consistency, reproducibility, construct validity, and ability to detect change. Results: This study supports the IBS-QOL as a psychometrically valid measure. Factor analyses suggested that IBS-specific QOL as measured by the IBS-QOL is a unidimensional construct. Construct validity was further buttressed by significant correlations between IBS-QOL total scores and related measures of IBS-d severity including the historically-relevant Irritable Bowel Syndrome Adequate Relief (IBS-AR) item and the FDA's Clinical Responder definition. The IBS-QOL also showed a significant ability to detect change as evidenced by analysis of treatment effects. A minority of the items, unrelated to the IBS-d, performed less well by the standards set by the original authors. Conclusions: We established that the IBS-QOL total score is a psychometrically valid measure of HRQOL in IBS-d patients enrolled in this study. Our analyses suggest that the IBS-QOL items demonstrate very good construct validity and ability to detect changes due to treatment effects. Furthermore, our analyses suggest that the IBS-QOL items measure a univariate construct and we believe further modeling of the IBS-QOL from an item response theory (IRT) approach under both non-treatment and treatment conditions would greatly further our understanding as item-based methods could be used to develop a short form. [Description provided by NIOSH]
• Subjects:
  Digestive System Digestive System Diseases Mental Health Occupational Health Safety Surveys And Questionnaires
• Keywords:
  Author Keywords: IBS-QOL Diarrhea Digestive System Eluxadoline Gastrointestinal System Disorders HRQOL Irritable Bowel Syndrome Patient-reported Outcomes Psychological Effects Psychometrics Quality Of Life Questionnaires

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• ISSN:
  1477-7525
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  North Carolina ; OSHA Region 10 ; OSHA Region 4 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  11
• NIOSHTIC Number:
  nn:20055414
• Citation:
  Health Qual Life Outcomes 2013 Dec; 11:208
• Contact Point Address:
  David A. Andrae, Furiex Pharmaceuticals, Inc., 3900 Paramount Parkway, Suite 150, Morrisville, NC 27560, USA
• Email:
  David.Andrae@furiex.com
• Federal Fiscal Year:
  2014
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Health and Quality of Life Outcomes
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2d7d4985066411dc6a945480e58a5d512cb2461fd0c694562221b182f8237d3809d9ec8ba19346ad2a2925b1b197b4da9fbf833cc5fc014799527c183f907a1b
• Download URL:
  https://stacks.cdc.gov/view/cdc/213273/cdc_213273_DS1.pdf
• File Type:
  [PDF - 407.03 KB ]