Chronic Exposure to Carbon Black Ultrafine Particles Reprograms Macrophage Metabolism and Accelerates Lung Cancer

Details

• Personal Author:
  Armstrong D ; Bandi A ; Becerra-Dominguez L ; Burkhardt PM ; Burt BM ; Catic A ; Chang C-Y ; Cheng Y-T ; Corry DB ; Kheradmand F ; Knight JM ; Lee H-S ; Madison MC ; Maneix L ; Marcano DC ; McHugh EA ; Phillips, Patrick E. ; Porter P ; Putluri N ; Song L ; Tour JM ; Tung H-Y ; Wu Y ; You R ; Yuan X ; Zeng Z
• Description:
  Chronic exposure to airborne carbon black ultrafine (nCB) particles generated from incomplete combustion of organic matter drives IL-17A-dependent emphysema. However, whether and how they alter the immune responses to lung cancer remains unknown. Here, we show that exposure to nCB particles increased PD-L1+ PD-L2+ CD206+ antigen-presenting cells (APCs), exhausted T cells, and Treg cells. Lung macrophages that harbored nCB particles showed selective mitochondrial structure damage and decreased oxidative respiration. Lung macrophages sustained the HIF1alpha axis that increased glycolysis and lactate production, culminating in an immunosuppressive microenvironment in multiple mouse models of non-small cell lung cancers. Adoptive transfer of lung APCs from nCB-exposed wild type to susceptible mice increased tumor incidence and caused early metastasis. Our findings show that nCB exposure metabolically rewires lung macrophages to promote immunosuppression and accelerates the development of lung cancer. [Description provided by NIOSH]
• Subjects:
  Blood Immune System Lung Lung Diseases Macrophages Neoplasms Occupational Health Oxidants Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Carbon Black Immune Reaction Immunology Inhalation Lung Cancer Oxidative Processes Respiration Respiratory Health Respiratory System Disorders Ultrafine Particles
• ISSN:
  2375-2548
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  8
• Issue:
  46
• NIOSHTIC Number:
  nn:20066426
• Citation:
  Sci Adv 2022 Nov; 8(46):eabq0615
• Contact Point Address:
  Farrah Kheradmand, Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA
• Email:
  farrahk@bcm.edu
• CAS Registry Number:
  Carbon black (CAS RN 1333-86-4)
• Federal Fiscal Year:
  2023
• Performing Organization:
  University of Texas Health Science Center, Houston
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Science Advances
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3a9d4bfbccf9caa8a167bd55c012cf789e9ca12332375007ecdabfd272796aaf49c6eee4eba5147454e74e056648c0fdc3a353816431d72ad024876b1e5c7358
• Download URL:
  https://stacks.cdc.gov/view/cdc/212856/cdc_212856_DS1.pdf
• File Type:
  [PDF - 10.02 MB ]