Breast Cancer Incidence in a Cohort of US Female Flight Attendants: Exposure-Response Analyses

Details

• Personal Author:
  Anderson J ; Hein M ; Little M ; Pinkerton L ; Schubauer-Berigan, Mary K. ; Sigurdson A
• Description:
  Objective: To examine the association of breast cancer incidence with cosmic radiation dose and metrics of circadian rhythm disruption, adjusted for non-occupational breast cancer risk factors, in a cohort of 6,093 US female flight attendants. Methods: We evaluated the association of breast cancer incidence with cumulative cosmic radiation absorbed dose, time spent working during the standard sleep interval, and time zones crossed (all lagged by ten years) using Cox regression. Individual exposure estimates were derived by linking work history data with domicile- and era- specific exposure estimates. Breast cancers were identified from telephone interviews and state cancer registries, and covariate data were obtained from telephone interviews. Results: Breast cancer incidence in the overall cohort was not associated with exposure. Significant, positive associations in breast cancer incidence were observed with all three exposures only among women with parity of three or more. Adjusted excess relative risks (95% confidence intervals) for women with parity of three or more were 1.6 (0.14 -6.6), 0.99 (-0.04-4.3), and 1.5 (0.14-6.2) per 10mGy, per 2000 hours spent working in the standard sleep interval, and per 4600 time zones crossed, respectively. Conclusions: Positive exposure-response relations occurred only in a small subset of the cohort. We recommend that future studies of breast cancer incidence in flight crew and other workers with circadian rhythm disruption assess interaction with parity to see if our findings are confirmed. [Description provided by NIOSH]
• Subjects:
  Circadian Rhythm Occupational Health Safety Sleep
• Keywords:
  Breast Cancer Circadian Rhythms Cosmic Radiation Flight Personnel Radiation Exposure
• Publisher:
  Society for Epidemiologic Research
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Colorado ; Ohio ; OSHA Region 5 ; OSHA Region 8 ; Utah
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20066355
• Citation:
  48th Annual Society for Epidemiologic Research (SER) Meeting, June 16-19, 2015, Denver, Colorado. Clearfield, UT: Society for Epidemiologic Research, 2015 Jun; :111
• Contact Point Address:
  Lynne Pinkerton, National Institute for Occupational Safety and Health, Cincinnati, OH
• Federal Fiscal Year:
  2015
• Peer Reviewed:
  False
• Source Full Name:
  48th Annual Society for Epidemiologic Research (SER) Meeting, June 16-19, 2015, Denver, Colorado
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5abec86b30432590766a70f17856a47975c52905ae4649674d1a63d5c5538d25e9f6d8c2d553bb0ddb178a4634e41dece53a52d406b041d95e7746d9c43bc247
• Download URL:
  https://stacks.cdc.gov/view/cdc/212821/cdc_212821_DS1.pdf
• File Type:
  [PDF - 672.62 KB ]