Longitudinal Associations Between Objective Sleep and Lipids: The CARDIA Study

Details

• Personal Author:
  Carnethon MR ; Glasser SJ ; Kim Y ; Knutson K ; Lauderdale D ; Lewis CE ; Reis JP ; Ruiter Petrov ME
• Description:
  Study Objective: To investigate the longitudinal relationships between actigraph-derived sleep duration, fragmentation, and lipid levels. Design and Setting: Longitudinal data from the Coronary Artery Risk Development in Young Adults Sleep Study (2003-05), an observational cohort at the Chicago site. Participants: There were 503 black and white adults, ages 32-51 years, with no prior history of cardiovascular disease. Interventions: N/A. Measurement and Results: Sleep duration and fragmentation were measured using 6 days of wrist actigraphy. Sleep quality was measured with the Pittsburgh Sleep Quality Index. The outcome variables, measured at 3 examinations over 10 years (Baseline [2000-01], 5-year [2005-06], and 10-year follow-up [2010-11]), were total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TG), and TC/HDL ratio. The associations between each sleep parameter and 10-year change in lipids were analyzed with generalized estimating equation models adjusting for relevant confounders. After adjustment, each hour increase in sleep duration was significantly associated with higher TC (5.2 mg/dL, 95%CI: 1.7, 8.6) and LDL (3.4 mg/dL, 95%CI: 0.2, 6.6) in the total sample, a 1.1 mg/dL increase in TG (95%CI: 1.0, 1.1) among men, and a borderline significant greater odds for a TC/HDL ratio >/= 5 among men (OR: 1.37, 95%CI: 0.99, 1.90). Overall, sleep fragmentation and sleep quality scores were not associated with change in lipids. Conclusions: Beyond relevant covariates, over a 10-year follow-up, longer objective sleep duration was longitudinally and significantly associated with a poorer lipid profile. Greater objective sleep fragmentation and self-reported poor sleep quality were not related to a poorer lipid profile. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Energy Metabolism Epidemiology Lipids Occupational Health Race Factors Safety Sex Characteristics Sleep Sleep Initiation And Maintenance Disorders

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• Keywords:
  Author Keywords: Sleep Duration Cardiovascular Disease Ethnicity Gender Factors Lipid Disorders Metabolic Effects Population Based Studies Racial Factors Sex Sex Factors Sleep Deprivation Sleep Disorders Sleep Fragmentation Sleep Quality Sociological Factors

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• ISSN:
  0161-8105
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Alabama ; Arizona ; Illinois ; Maryland ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  36
• Issue:
  11
• NIOSHTIC Number:
  nn:20052755
• Citation:
  Sleep 2013 Nov; 36(11):1587-1595
• Contact Point Address:
  Megan E. Petrov, PhD, Arizona State University, College of Nursing and Health Innovation, 500 N. 3rd St., Phoenix, AZ 85004-0698, MC 3020
• Email:
  Megan.Petrov@asu.edu
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Healthcare and Social Assistance
• Performing Organization:
  University of Chicago
• Peer Reviewed:
  True
• Start Date:
  20090901
• Source Full Name:
  Sleep
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a45b7a8b1806f5e2647b6fd595823feebb39927a9891ca0d0a6181ee9378e6bb9dc1e91de04702a8cd5ff67e4472fe2cb4671a9015a45932bd60543b4cec6710
• Download URL:
  https://stacks.cdc.gov/view/cdc/212233/cdc_212233_DS1.pdf
• File Type:
  [PDF - 307.06 KB ]