Rapid Neutralization of Organophosphate Nerve Gas Agents

Details

• Personal Author:
  Arment AR ; Gao D
• Description:
  This study had the following aims: 1) Isolate and identify microorganisms able to bioremediate malathion as a sole source of carbon, sulfur and phosphorus; 2) Study the kinetics of malathion bioremediation by comparative analysis of substrate disappearance and novel product appearance over time by GC-MS; 3) Screen the organisms for the ability to metabolize the abiotic byproducts of VX degradation, e.g. EMPA, DIEM; 4) Study the kinetics of EMPA, DIEM bioremediation by comparative analysis of substrate disappearance and novel product appearance over time by GC-MS; 5)Study the genetics of positive organisms to identify and isolate specific genes and proteins involved in byproduct bioremediation; 6) Clone and express degrading proteins for protein purification. [Description provided by NIOSH]
• Subjects:
  Genetics Hazardous Substances Insecticides Microbiology Occupational Health Organophosphates Safety
• Keywords:
  Chemical Warfare Agents Genes Malathion Microorganisms Organophosphorus Pesticides Proteins Remediation Synthetic Materials Toxins
• Publisher:
  University of Cincinnati
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Proceedings
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-35
• NIOSHTIC Number:
  nn:20052570
• Citation:
  14th Annual Pilot Research Project Symposium, University of Cincinnati Education and Research Center, October 10-11, 2013, Cincinnati, Ohio. Cincinnati, OH: University of Cincinnati, 2013 Oct; :1-35
• CAS Registry Number:
  Malathion (CAS RN 121-75-5)
• Federal Fiscal Year:
  2014
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  14th Annual Pilot Research Project Symposium, University of Cincinnati Education and Research Center, October 10-11, 2013, Cincinnati, Ohio
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bb1dd08a24d6a0c4e26f7f8b00c1e7615f7b54667a9eee80d20cb3492b5be65ecb754ba0c290a11f299d65f5c1c5eff1406f2150fa17ab52827eb5df103f5ff0
• Download URL:
  https://stacks.cdc.gov/view/cdc/212079/cdc_212079_DS1.pdf
• File Type:
  [PDF - 1.07 MB ]