Endotoxin Exposures in Size-Specific Airborne Particles in & out of the Workplace

Details

• Personal Author:
  Adhikari A ; Bernstein JA ; Singh U
• Description:
  The hypothesis of this project is as follows: Induction of nitrative stress and the inflammatory response in human bronchoepithelial cells with endotoxin exposures (at equivalent concentrations) would vary significantly depending on the size of endotoxin particles (i.e., da<1.0 and >1.8 um). The specific aims of this project are as follows: Aim 1: To determine nitrative stress induction and Aim 2: To determine gene expression regulating inflammatory responses in human bronchoepithelial cells after exposures to (similar concentrations of) endotoxin derived from size-specific airborne particles (i.e., in particles < 1 um and >1.8 um). [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Endotoxins Immune System Occupational Health Particulate Matter Safety
• Keywords:
  Airborne Particulates Bacteria Bioaerosols Cell Signaling Cellular Structures Immune Reaction In Vitro Study Molecular Biology Particle Size Pathogens
• Publisher:
  University of Cincinnati
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Proceedings
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-19
• NIOSHTIC Number:
  nn:20052556
• Citation:
  14th Annual Pilot Research Project Symposium, University of Cincinnati Education and Research Center, October 10-11, 2013, Cincinnati, Ohio. Cincinnati, OH: University of Cincinnati, 2013 Oct; :1-19
• Federal Fiscal Year:
  2014
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  14th Annual Pilot Research Project Symposium, University of Cincinnati Education and Research Center, October 10-11, 2013, Cincinnati, Ohio
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8118c844fc9046e6a2b385c004e2dbbdf59fdb60675b524c6ededf6f42a69e970edfe7c2b0e6df673e22b69f412f401d01bdbd968625ef6ba3fee60ce1e87526
• Download URL:
  https://stacks.cdc.gov/view/cdc/212067/cdc_212067_DS1.pdf
• File Type:
  [PDF - 1.01 MB ]