Is the Mast Cell a Key Player in Vibration Disease?

Details

• Personal Author:
  Bain JLW ; Riley, Danny A.
• Description:
  Hand arm vibration syndrome (HAVS) involves pathological changes in multiple tissues. Lowering injury requires understanding the primary cellular targets of vibration exposure. Impact vibration generates immediate mast cell degranulation and causes skin hypersensitivity to noxious heat. Mast cells secrete histamine which increases sensory nerve excitability. In this study, we developed methods to cut whole cross sections of the rat tail for global analysis of mast cells. Mast cells are numerous and widely distributed throughout the skin and the connective tissues that support arteries, veins, nerves, skeletal muscles and tendons in the tail. Similar distribution patterns of mast cells occur in human hands and feet. Vibration magnitude and frequency influence the course of HAVS. In the present study, we compared the acute effects of sinusoidal and impact shock wave vibration on mast cell degranulation. [Description provided by NIOSH]
• Subjects:
  Animals Environmental Exposure Hot Temperature Hypersensitivity Laboratories Occupational Health Pathology Risk Assessment Risk Factors Safety Skin Vibration

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• Keywords:
  Cell Damage Cellular Effects Exposure-levels Exposure Levels Hand-arm Vibration Syndrome HAVS Heat Histamines Injuries Laboratory Animals Risk-factors Risk Factors Skin Sensitivity Tissue Disorders Vibration-effects Vibration-exposure

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• Publisher:
  University of Connecticut Health Center
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 5 ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  55-56
• NIOSHTIC Number:
  nn:20052503
• Citation:
  Proceedings of the 4th American Conference on Human Vibration: Fostering Collaborative Academic, Clinical, and Industrial Research in Vibration Exposure and Control, June 13-15, 2012, Hartford, Connecticut. Peterson DR, Asaki T, eds. Farmington, CT: University of Connecticut Health Center, 2012 Jun; :55-56
• Editor(s):
  Peterson DR; Asaki T
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Construction
• Performing Organization:
  Medical College of Wisconsin, Milwaukee, Wisconsin
• Peer Reviewed:
  False
• Start Date:
  19990901
• Source Full Name:
  Proceedings of the 4th American Conference on Human Vibration: Fostering Collaborative Academic, Clinical, and Industrial Research in Vibration Exposure and Control, June 13-15, 2012, Hartford, Connecticut
• End Date:
  20160831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c47785bbd0fb670b79f3f3e35f649d6ba7817573599e2ea60752ff4f95b4d058b68ce947e2ecf2877dc0356b2a2e4feeb0c6cd6273d22b5a23c9575a7430494b
• Download URL:
  https://stacks.cdc.gov/view/cdc/212017/cdc_212017_DS1.pdf
• File Type:
  [PDF - 226.47 KB ]