The Preventive Effects of Apolipoprotein Mimetic D-4F from Vibration Injury-Experiment in Rats

Details

• Personal Author:
  Kao DS ; Matloub, Hani S. ; Pritchard KA Jr. ; Riley, Danny A. ; Rowe DJ ; Yan J-G ; Zhang LL
• Description:
  Hand-arm vibration syndrome (HAVS) is a debilitating sequela of neurological and vascular injuries caused by prolonged occupational exposure to hand-transmitted vibration. Our previous study demonstrated that short-term exposure to vibration can induce vasoconstriction and endothelial cell damage in the ventral artery of the rat's tail. The present study investigated whether pretreatment with D-4F, an apolipoprotein A-1 mimetic with known anti-oxidant and vasodilatory properties, prevents vibration-induced vasoconstriction, endothelial cell injury, and protein nitration. Rats were injected intraperitoneally with 3 mg/kg D-4F at 1 h before vibration of the tails for 4 h/day at 60 Hz, 49 m/s2 r.m.s. acceleration for either 1 or 3 days. Vibration-induced endothelial cell damage was examined by light microscopy and nitrotyrosine immunoreactivity (a marker for free radical production). One and 3-day vibration produced vasoconstriction and increased nitrotyrosine. Preemptive treatment with D-4F prevented these negative changes. These findings suggest that D-4F may be useful in the prevention of HAVS. [Description provided by NIOSH]
• Subjects:
  Animals Antioxidants Environmental Exposure Laboratories Musculoskeletal System Nervous System Nervous System Diseases Occupational Health Risk Assessment Risk Factors Safety Vibration

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• Keywords:
  Apolipoprotein Mimetic Author Keywords: Occupational Raynauds D-4F Endothelial Cell Injury Endothelial Cells Exposure Levels Hand-arm Vibration Syndrome Hand Arm Vibration Syndrome Hand Injuries HAVS Injuries Laboratory Animals Neurological Disorders Proteins Risk Factors Vasoconstriction Vibration Effects Vibration Exposure Vibration Injury

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• ISSN:
  1558-9447
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 5 ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  64-70
• Volume:
  6
• Issue:
  1
• NIOSHTIC Number:
  nn:20052497
• Citation:
  Hand 2011 Mar; 6(1):64-70
• Contact Point Address:
  J. G. Yan, Department of Plastic Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226
• Email:
  jyan@mcw.edu
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Construction
• Performing Organization:
  Medical College of Wisconsin, Milwaukee, Wisconsin
• Peer Reviewed:
  True
• Start Date:
  19990901
• Source Full Name:
  Hand
• End Date:
  20160831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7c558e321634d426ebb736ca20e78b22fb7ac2b073827e8bcc041f6be803c2bee636e4f9cb72925b82fb9823955aeff99cdb6703b4abddc0228ae00b2bd3967d
• Download URL:
  https://stacks.cdc.gov/view/cdc/212012/cdc_212012_DS1.pdf
• File Type:
  [PDF - 314.49 KB ]