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Enhanced Capture of Microbeads for Water Treatment



Details

  • Personal Author:
  • Description:
    In micro total analysis systems, detection of pathogens and isolation of biomolecules by immunoassays is essential for point-of-care diagnostics. Magnetophoretic separation, which uses magnetic microbeads coated with specific epitopes to entrap target pathogens, is a common method used in microfluidic platforms. However, the difficulty with these platforms is efficient capture of microbeads. The purpose of this study is to analyze a microfluidic device that utilizes electroosmotic flow and flow switching to increase capture efficiency in a portable chip device. Electroosmotic flow enables easy switching through the changing of voltage between two electrodes to increase the amount of time beads spend under the influence of the magnetic field, thereby increasing the capture effectiveness. This project will analyze the capture efficiency of the system using fluorescently tagged microbeads, as well as characterize the secondary capture of bacteria in a sample. This device will be used to analyze water systems and determine the concentration of bacteria in a water system through the use of beads coated with epitopes targeted to specific bacteria. This technology is a unique platform that allows for rapid and accurate analysis in a portable device that can be used in on site, point of care situations. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • Publisher:
    University of Cincinnati
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Abstract or Summary
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Pages in Document:
    1
  • NIOSHTIC Number:
    nn:20052454
  • Citation:
    17th Annual Pilot Research Project Symposium, University of Cincinnati Education and Research Center, October 13-14, 2016, Cincinnati, Ohio. Cincinnati, OH: University of Cincinnati, 2016 Oct; :1
  • Email:
    mille4sa@mail.uc.edu
  • Federal Fiscal Year:
    2017
  • Performing Organization:
    University of Cincinnati
  • Peer Reviewed:
    True
  • Start Date:
    20050701
  • Source Full Name:
    17th Annual Pilot Research Project Symposium, University of Cincinnati Education and Research Center, October 13-14, 2016, Cincinnati, Ohio
  • End Date:
    20260630
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:1c5c8fcd8873a2125c8668390e3d9d2f620464609936cc7cf8f3ef77166429a1262820b2ea963d85b7342d4f5cae0701ae4c4193a8a9e177dfd22aa0a6cd302f
  • Download URL:
  • File Type:
    Filetype[PDF - 84.00 KB ]
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