Indoor Air Quality and Non-IgE-Mediated Immunologic Respiratory Disease

Details

• Personal Author:
  Lewis, Daniel M. ; Parker, John E. ; Siegel, Paul D.
• Description:
  Humidifier fever and humidifier lung represent and respiratory responses to the inhalation of organic dust. Both of these illnesses can follow exposures to bioaerosols created by contaminated heating, ventilation, and air conditioning units. These disorders share several clinical features, including fever and respiratory symptoms, as well as certain laboratory finding. The high attack rate observed in clusters of individuals with humidifier fever suggest exposure: dose may be more important than host factors. In contrast, immunologic or host factors appear to be important in the development of humidifier lung, a form of hypersensitivity pneumonitis. The diagnostic work-ups for these diseases are similar, although therapeutic approaches differ. This article presents information on current theories of the pathogenesis of these disorders derived from laboratory, clinical, and epidemiologic studies. [Description provided by NIOSH]
• Subjects:
  Air Pollution, Indoor Asthma Asthma, Occupational Dust Occupational Health Safety
• Keywords:
  Bronchitis Hypersensitivity Pneumonitis IEQ Indoor Environmental Quality Metal Fume Fever ODTS Organic Dusts Organic Dust Toxic Syndrome
• ISSN:
  0889-8561
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  14
• Issue:
  3
• NIOSHTIC Number:
  nn:20052308
• Citation:
  Immunol Allergy Clin North Am 1994 Aug; 14(3):591-605
• Contact Point Address:
  John E. Parker, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, West Virginia
• Federal Fiscal Year:
  1994
• Peer Reviewed:
  True
• Source Full Name:
  Immunology and Allergy Clinics of North America
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:89634e9ac0193500d940d0b3235b6657caf8bc8970cdbf6a11a51e56e9d475b1f0753fa93993aaf15967fb75c9b38dfc8625a1e76f37e18ccfce3003dc448f43
• Download URL:
  https://stacks.cdc.gov/view/cdc/211853/cdc_211853_DS1.pdf
• File Type:
  [PDF - 1.89 MB ]