Effects of Bisphenol A and Its Analogs on Reproductive Health: A Mini Review

Details

• Personal Author:
  Liang S ; Measel E ; Siracusa JS ; Yin L ; Yu X
• Description:
  Known endocrine disruptor bisphenol A (BPA) has been shown to be a reproductive toxicant in animal models. Its structural analogs: bisphenol S (BPS), bisphenol F (BPF), bisphenol AF (BPAF), and tetrabromobisphenol A (TBBPA) are increasingly being used in consumer products. However, these analogs may exert similar adverse effects on the reproductive system, and their toxicological data are still limited. This mini-review examined studies on both BPA and BPA analog exposure and reproductive toxicity. It outlines the current state of knowledge on human exposure, toxicokinetics, endocrine activities, and reproductive toxicities of BPA and its analogs. BPA analogs showed similar endocrine potencies when compared to BPA, and emerging data suggest they may pose threats as reproductive hazards in animal models. While evidence based on epidemiological studies is still weak, we have utilized current studies to highlight knowledge gaps and research needs for future risk assessments. [Description provided by NIOSH]
• Subjects:
  Cytology Endocrine System Laboratories Occupational Health Safety Toxicology Urogenital System
• Keywords:
  Author Keywords: Bisphenol A Bisphenol A Bisphenol AF Bisphenol F Bisphenol S Endocrine Disruptors Germ Cells In Vitro Study Laboratory Animals Reproductive Effects Reproductive Hazards Reproductive Toxicity Tetrabromobisphenol A

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• ISSN:
  0890-6238
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Maryland ; OSHA Region 3 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  96-123
• Volume:
  79
• NIOSHTIC Number:
  nn:20052257
• Citation:
  Reprod Toxicol 2018 Aug; 79:96-123
• Contact Point Address:
  Xiaozhong Yu, Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, GA 30602, United States
• Email:
  yuxz@uga.edu
• CAS Registry Number:
  2,2-Bis(4-hydroxyphenyl)propane (CAS RN 80-05-7)
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of Georgia, Athens
• Peer Reviewed:
  True
• Start Date:
  20130901
• Source Full Name:
  Reproductive Toxicology
• End Date:
  20160831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:eb937cd8939edbc95542fa6a75c1d25ced42d9682b0b46b5388a52f566563e2419ebca7b2ef895586686a4e1ca6c332229ecf5c750f4824e29198612424a10a6
• Download URL:
  https://stacks.cdc.gov/view/cdc/211812/cdc_211812_DS1.pdf
• File Type:
  [PDF - 366.40 KB ]