Respiratory Health and Lung Function in Children Exposed to the World Trade Center Disaster

Details

• Personal Author:
  Attina TM ; Berger KI ; Gilbert J ; Giusti R ; Goldring RM ; Han X ; Koshy TT ; Marmor M ; Naidu M ; Shao Y ; Trasande L ; Tyre A
• Description:
  Objectives To compare lung function in a representative sample of World Trade Center (WTC)-exposed children with matched comparisons, and examine relationships with reported exposures. Study design Study population consisted of 402 participants. Oscillometry, spirometry, and plethysmography were performed on WTC Health Registry (WTCHR) respondents who were .8 years of age on September 11, 2001 (n = 180) and a sociodemographically matched group of New York City residents (n = 222). We compared lung function by study arm (WTCHR and comparison group) as well as dust cloud (acute); home dust (subchronic); and other traumatic, nondust exposures. Results In multivariable models, post-9/11 risk of incident asthma was higher in the WTCHR participants than in the comparison group (OR 1.109, 95% CI 1.021, 1.206; P = .015). Comparing by exposure rather than by group, dust cloud (OR 1.223, 95% CI 1.095, 1.365; P < .001) and home dust (OR 1.123, 95% CI 1.029, 1.226; P = .009) exposures were also associated with a greater risk of incidence of post-9/11 asthma. No differences were identified for lung function measures. Conclusions Although we cannot exclude an alternative explanation to the null findings, these results may provide some measure of reassurance to exposed children and their families regarding long-term consequences. Further study with bronchodilation and/or methacholine challenge may be needed to identify and further evaluate effects of WTC exposure. Biomarker studies may also be more informative in delineating exposure-outcome relationships. [Description provided by NIOSH]
• Subjects:
  Demography Dust Environmental Exposure Hazardous Substances Lung Occupational Health Respiratory Function Tests Respiratory System Risk Assessment Risk Factors Safety September 11 Terrorist Attacks

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• Keywords:
  Children Demographic Characteristics Dust Exposure Dusts Exposure Levels Health Effects Humans Lung Function Oscillography Plethysmography Respiratory Function Respiratory Health Risk Factors Sociological Factors Spirometry Statistical Analysis Toxins World Trade Center WTC

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• ISSN:
  0022-3476
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  134-140
• Volume:
  201
• NIOSHTIC Number:
  nn:20052083
• Citation:
  J Pediatr 2018 Oct; 201:134-140
• Contact Point Address:
  Leonardo Trasande, MD, MPP, Department of Pediatrics, New York University School of Medicine, 403 East 34th St Rm 115, New York, NY 10016
• Email:
  leonardo.trasande@nyumc.org
• Federal Fiscal Year:
  2019
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20130701
• Source Full Name:
  The Journal of Pediatrics
• End Date:
  20170630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:645f6fd630385e7407e0dc3139208903df1c66cd8b1118535a0ff33b2ade689e4bd4f24e7e1ebadc99e6786febbbdfec584c5fa8c8764978045638ba931c3f2d
• Download URL:
  https://stacks.cdc.gov/view/cdc/211683/cdc_211683_DS1.pdf
• File Type:
  [PDF - 2.09 MB ]