Chromosome Translocations and Cosmic Radiation Dose in Male U.S. Commercial Airline Pilots

Details

• Personal Author:
  Bertke SJ ; Bhatti P ; Grajewski, Barbara A. ; Little MP ; Ramsey MJ ; Sigurdson AJ ; Tucker JD ; Ward, Elizabeth M. ; Waters MA ; Whelan, Elizabeth A. ; Yong LC
• Description:
  BACKGROUND: Chromosome translocations are a biomarker of cumulative exposure to ionizing radiation. We examined the relation between the frequency of translocations and cosmic radiation dose in 83 male airline pilots. METHODS: Translocations were scored using fluorescence in situ hybridization chromosome painting. Cumulative radiation doses were estimated from individual flight records. Excess rate and log-linear Poisson regression models were evaluated. RESULTS: Pilots' estimated median cumulative absorbed dose was 15 mGy (range 4.5-38). No association was observed between translocation frequency and absorbed dose from all types of flying [rate ratio (RR) = 1.01 at 1 mGy, 95% confidence interval (CI) 0.97-1.04]. However, additional analyses of pilots' dose from only commercial flying suggested an association (RR = 1.04 at 1 mGy, 95% CI 0.97-1.13). DISCUSSION: Although this is the largest cytogenetic study of male commercial airline pilots to date of which the authors are aware, future studies will need additional highly exposed pilots to better assess the translocation-cosmic radiation relation. [Description provided by NIOSH]
• Subjects:
  Circadian Rhythm Men Occupational Health Radiation Safety
• Keywords:
  Author Keywords: Aircrew Chromosome Disorders Chromosome Translocations Circadian Disruption Circadian Rhythms Cosmic Radiation Humans Ionizing Radiation Models Pilots Radiation Exposure Statistical Analysis

  More +
• ISSN:
  2375-6314
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5 ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  89
• Issue:
  7
• NIOSHTIC Number:
  nn:20052038
• Citation:
  Aerosp Med Hum Perform 2018 Jul; 89(7):616-625
• Contact Point Address:
  Barbara Grajewski, Ph.D., Division of Public Health, 1 W. Wilson St., Room 150, Madison, WI 53701
• Email:
  barbara.grajewski@dhs.wisconsin.gov
• Federal Fiscal Year:
  2018
• NORA Priority Area:
  Transportation, Warehousing and Utilities ; Manufacturing
• Performing Organization:
  Wisconsin Department of Health Services, Madison
• Peer Reviewed:
  True
• Start Date:
  20150701
• Source Full Name:
  Aerospace Medicine and Human Performance
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3418f342527233593954ae4a0d0e5c15f393cf4a34bad870e30aa040f9faf6b34b68e10f4cc61d798fbf2f6ccaa2c988193d9faf47721069c644895d44a4f1da
• Download URL:
  https://stacks.cdc.gov/view/cdc/211649/cdc_211649_DS1.pdf
• File Type:
  [PDF - 602.39 KB ]