Alternaria Is Associated with Asthma Symptoms and Exhaled NO Among NYC Children

Details

• Personal Author:
  Acosta L ; Divjan A ; Goldstein IF ; Green, Brett J. ; Jacobson JS ; Lemons, Angela R. ; Miller RL ; Perzanowsk MS ; Rundle AG ; Sobek E ; Soffer N
• Description:
  Alternaria alternata was detected in settled dust in most NYC homes, suggesting that domestic exposure is common. Sensitization to A. alternata, including at concentrations of IgE previously considered to be negative (0.1 - <0.35 IU/ml), was associated with asthma morbidity, independent of sensitization to other common inhalant allergens. A. alternata measured in settled dust was associated with increased FeNO, an association that appeared to be stronger for children living in neighborhoods with higher airborne elemental carbon particulate matter. Capsule summary: Among NYC children, Alternaria sensitization, even at low IgE concentrations, was associated with asthma morbidity. Domestic Alternaria exposure, which was common, was associated with exhaled NO, specifically among children with higher neighborhood-level combustion air pollution. [Description provided by NIOSH]
• Subjects:
  Asthma Asthma, Occupational Dust Fungi Hypersensitivity Immune System Occupational Health Safety
• Keywords:
  Allergens Allergy Author Keywords: IgE Children Dust Exposure Immunoglobulins Plant Dusts Quantitative Polymerase Chain Reaction Sensitization
• ISSN:
  0091-6749
• Document Type:
  Text
• Funding:
  Interagency Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4 ; Tennessee ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  142
• Issue:
  4
• NIOSHTIC Number:
  nn:20052004
• Citation:
  J Allergy Clin Immunol 2018 Oct; 142(4):1366-1368
• Contact Point Address:
  Matthew S. Perzanowski, Ph.D., Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722 West 168th Street, 11th floor, New York, New York 10032
• Federal Fiscal Year:
  2019
• NORA Priority Area:
  Healthcare and Social Assistance ; Services
• Peer Reviewed:
  False
• Source Full Name:
  Journal of Allergy and Clinical Immunology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f2ac75009e7a97a60e65fbdb9fad0f97bf6836ed7e78f8eacfa4100ee1e8e0dfe8c57867ed8b5039d77ee3d233941643d5d7e438eb22b2b97ef7359233c38809
• Download URL:
  https://stacks.cdc.gov/view/cdc/211636/cdc_211636_DS1.pdf
• File Type:
  [PDF - 227.48 KB ]