Is There an Association Between Ambient Air Pollution and Bladder Cancer Incidence? Analysis of 15 European Cohorts

Details

• Personal Author:
  Aamodt G ; Amiano P ; Andersen ZJ ; Beelen R ; Brunekreef B ; Bueno-de-Mesquita B ; Cesaroni G ; Concin H ; De Faire U ; de Hoogh K ; Dorronsoro M ; Eeftens M ; Eriksen KT ; Forastiere F ; Forsberg B ; Fratiglioni L ; Galassi C ; Grioni S ; Hoek G ; Jaensch A ; Key TJ ; Kogevinas M ; Korek M ; Krog NH ; Krogh V ; Marcon A ; Nagel G ; Nieuwenhuijsen MJ ; Oftedal B ; Olsson D ; Östenson C-G ; Pedersen M ; Pedersen NL ; Peeters PH ; Pershagen G ; Plusquin M ; Pyko A ; Raaschou-Nielsen O ; Ranzi A ; Ricceri F ; Sacerdote C ; Sokhi R ; Sommar J ; Sørensen M ; Stafoggia M ; Stayner, Leslie T. ; Tamayo I ; Tjønneland A ; Tsai M-Y ; Vermeulen R ; Vineis P ; Wang M ; Weinmayr G
• Description:
  Background: Ambient air pollution contains low concentrations of carcinogens implicated in the etiology of urinary bladder cancer (BC). Little is known about whether exposure to air pollution influences BC in the general population. Objective: To evaluate the association between long-term exposure to ambient air pollution and BC incidence. Design, setting, and participants: We obtained data from 15 population-based cohorts enrolled between 1985 and 2005 in eight European countries (N = 303 431; mean follow-up 14.1 yr). We estimated exposure to nitrogen oxides (NO2 and NOx), particulate matter (PM) with diameter <10 microm (PM10), <2.5 microm (PM2.5), between 2.5 and 10 microm (PM2.5-10), PM2.5 absorbance (soot), elemental constituents of PM, organic carbon, and traffic density at baseline home addresses using standardized land-use regression models from the European Study of Cohorts for Air Pollution Effects project. Outcome measurements and statistical analysis: We used Cox proportional-hazards models with adjustment for potential confounders for cohort-specific analyses and meta-analyses to estimate summary hazard ratios (HRs) for BC incidence. Results and limitations: During follow-up, 943 incident BC cases were diagnosed. In the meta-analysis, none of the exposures were associated with BC risk. The summary HRs associated with a 10-microg/m3 increase in NO2 and 5-microg/m3 increase in PM2.5 were 0.98 (95% confidence interval [CI] 0.89-1.08) and 0.86 (95% CI 0.63-1.18), respectively. Limitations include the lack of information about lifetime exposure. Conclusions: There was no evidence of an association between exposure to outdoor air pollution levels at place of residence and risk of BC. Patient summary: We assessed the link between outdoor air pollution at place of residence and bladder cancer using the largest study population to date and extensive assessment of exposure and comprehensive data on personal risk factors such as smoking. We found no association between the levels of outdoor air pollution at place of residence and bladder cancer risk. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution Carcinogens Environment Environmental Exposure Environmental Pollution Neoplasms Occupational Health Particulate Matter Risk Assessment Risk Factors Safety Vehicle Emissions

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• Keywords:
  Airborne Particulates Air Pollutants Air Pollution Analytical Models Author Keywords: Air Pollution Bladder Cancer Cancer Cancer Rates Carbon Diesel Emissions Diesel Exhaust Disease Incidence Elements Emission Sources Environmental Exposure Environmental Pollution Etiology Exposure Assessment Long Term Exposure Nitrogen Oxides Organic Compounds Outdoors Particle Diameter Particle Size Particulates Population Based Studies Prevention Regression Analysis Risk Factors

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• ISSN:
  2405-4569
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; OSHA Region 10 ; OSHA Region 5 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  113-120
• Volume:
  4
• Issue:
  1
• NIOSHTIC Number:
  nn:20051980
• Citation:
  Eur Urol Focus 2018 Jan; 4(1):113-120
• Contact Point Address:
  Marie Pedersen, Centre for Epidemiology and Screening, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, 1014 København K, Denmark
• Email:
  mp@sund.ku.dk
• CAS Registry Number:
  Nitrogen dioxide (CAS RN 10102-44-0)
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of Illinois at Chicago
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  European Urology Focus
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:04c2bc6a411671f5db3c8ec0ef009a25a602c5275ef5522481ccd96c96a4eb4c5fb271628a5a7bcf0dbbbbbe8185a0aa6ec525f72034912f60a7d894be5ccfe7
• Download URL:
  https://stacks.cdc.gov/view/cdc/211619/cdc_211619_DS1.pdf
• File Type:
  [PDF - 548.28 KB ]