The Interaction of Dopamine Genes and Financial Stressors to Predict Adulthood Intimate Partner Violence Perpetration

Details

• Personal Author:
  Parker EA ; Peek-Asa, Corinne ; Schwab-Reese LM
• Description:
  Three dopamine genes (DAT1, DRD2, and DRD4) have been associated with interpersonal delinquency, aggression, and violence when individuals experience adverse environmental exposures. Guided by the catalyst model of aggression, risk alleles identified in previous studies were hypothesized to be associated with intimate partner violence (IPV) perpetration in the presence of financial stressors, a possible environmental trigger. This hypothesis was tested using weighted, clustered logistic regression with data from the National Longitudinal Study of Adolescent to Adult Health. The direct effects DAT1, DRD2, and DRD4 on IPV perpetration, and the interaction of DAT1, DRD2, and DRD4 and financial stressors on IPV perpetration were assessed. Due to cell size, only White men and women were included in this analysis. Increasing number of financial stressors was associated with increased odds of IPV perpetration, regardless of DAT1, DRD2, and DRD4 alleles. As predicted, increasing number of financial stressors was more strongly associated with IPV perpetration among individuals with high-risk DAT1 alleles, than individuals with low-risk alleles. However, this relationship was inverted for DRD2. Although there was still a significant interaction between DRD2 and financial stressors, individuals with low-risk alleles had higher odds of IPV perpetration in the presence of financial stressors. A similar, nonsignificant relationship was found for DRD4. These findings indicate that these genes may interact differently with environmental exposures and types of violent behavior. In addition, the findings may, if replicated, suggest dopamine plays a different role in IPV perpetration compared with other forms of aggression and violence. [Description provided by NIOSH]
• Subjects:
  Behavior Economics Environment Environmental Exposure Genetics Men Mental Health Occupational Health Risk Assessment Risk Factors Safety Stress, Psychological Violence Women

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• Keywords:
  Abuse Author Keywords: Intimate Partner Violence Biological Effects Brain Function Catecholamines Costs DAT1 Dopamine DRD2 DRD4 Environmental Exposure Environmental Factors Gene Expression Genes Humans Mental Stress Neurotransmitters Perpetration Physical Reactions Psychological Stress Regression Analysis Risk Factors Stress Violence Prevention

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• ISSN:
  0886-2605
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Iowa ; OSHA Region 7 ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  35
• Issue:
  5
• NIOSHTIC Number:
  nn:20051729
• Citation:
  J Interpers Violence 2020 Mar; 35(5-6):1251-1268
• Contact Point Address:
  Laura M. Schwab-Reese, Kempe Center for the Prevention and Treatment of Child Abuse and Neglect, Department of Pediatrics, School of Medicine, University of Colorado, Aurora, CO 80045, USA
• Email:
  laura.m.schwab@gmail.com
• CAS Registry Number:
  Dopamine (CAS RN 51-61-6)
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of Iowa
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Interpersonal Violence
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5caab583c0a8fa2086c4ce44ed8fed9e7ed8d5cfc74225fd8a8985d0764ed2d7257631f9cd8dee81b5de1d94fdf9cde9e52a1b4d1fe6a306bf9e86813d77db02
• Download URL:
  https://stacks.cdc.gov/view/cdc/211528/cdc_211528_DS1.pdf
• File Type:
  [PDF - 116.81 KB ]