Serum Mercury Concentration and the Risk of Ischemic Stroke: The Reasons for Geographic and Racial Differences in Stroke Trace Element Study

Details

• Personal Author:
  Brockman J ; Cai J ; Cheng C ; Cushman M ; He K ; Kamendulis L ; MacDonald L ; Mackey J ; McClure LA ; Xun P ; Brockman J ; Cai J ; Cheng C ; Cushman M ; He K ; Kamendulis L ; MacDonald L ; Mackey J ; McClure LA ; Xun P
• Description:
  Background: Although biologically plausible, epidemiological evidence linking exposure to methylmercury with increased risk of ischemic stroke is limited. The effects of methylmercury may be modified by selenium, which is an anti-oxidant that often co-exists with mercury in fish. Objectives: To examine the association between serum mercury levels with the incidence of ischemic stroke and to explore the possible effect modifications by serum selenium levels and demographic and geographic factors. Methods: A case-cohort study was designed nested in the REasons for Geographic and Racial Differences in Stroke cohort, including 662 adjudicated incident cases of ischemic stroke and 2494 participants in a randomly selected sub-cohort. Serum mercury was measured using samples collected at recruitment. Multivariable-adjusted hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were estimated using the Barlow-weighting method for the Cox proportional hazards regression model. Results: No statistically significant association was observed between serum mercury concentration and the incidence of ischemic stroke (the highest vs. lowest quintile of mercury levels: HR = 0.82; 95% CI = 0.55-1.22; P for linear trend = 0.42). Sex (P for interaction = 0.06), but not serum selenium levels, modified the association; a more evident trend toward lower incidence of ischemic stroke with higher mercury levels was observed among women. Conclusion: This study does not support an association between mercury and the incidence of ischemic stroke within a population with low-to-moderate level of exposure. Further studies are needed to explore the possibility of mercury-induced ischemic stroke toxicity in other populations at higher exposure levels. [Description provided by NIOSH]
• Subjects:
  Body Fluids Cardiovascular Diseases Cardiovascular System Cohort Studies Demography Environmental Exposure Hazardous Substances Mercury Occupational Health Race Factors Safety

  More +
• Keywords:
  Author Keywords: Mercury Body Fluids Case-cohort Study Cohort Studies Demographic Characteristics Elements Exposure Levels Heart Disease Humans Ischemic Stroke Mercury Compounds Methyl Compounds Nested Case Control Studies Racial Factors REGARDS Study Regression Analysis Selenium Selenium Compounds Toxic Materials

  More +
• ISSN:
  0160-4120
• Document Type:
  Text
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Indiana ; Missouri ; North Carolina ; Ohio ; OSHA Region 1 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 7 ; Pennsylvania ; Vermont
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  125-131
• Volume:
  117
• NIOSHTIC Number:
  nn:20051614
• Citation:
  Environ Int 2018 Aug; 117:125-131
• Contact Point Address:
  Ka He, Department of Epidemiology and Biostatistics, School of Public Health - Bloomington, Indiana University, 1025 E. Seventh Street, SPH C042, Bloomington, IN 47405, USA
• Email:
  kahe@indiana.edu
• CAS Registry Number:
  Mercury (CAS RN 7439-97-6) ; Methylmercury(1+) (CAS RN 22967-92-6) ; Selenium (CAS RN 7782-49-2) ; Mercury (CAS RN 7439-97-6) ; Methylmercury(1+) (CAS RN 22967-92-6) ; Selenium (CAS RN 7782-49-2)
• Federal Fiscal Year:
  2018
• Peer Reviewed:
  True
• Source Full Name:
  Environmental International
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4345c5645209106670ee20fed12cb049b4e15104921efe7d8fe4a5c0678deb5f83284cc0d59eeef32c6f9517468cb2e973a26a2d3d93cea47b95660429b2bdd4
• Download URL:
  https://stacks.cdc.gov/view/cdc/211477/cdc_211477_DS1.pdf
• File Type:
  [PDF - 232.39 KB ]