Development of a Physiological Frailty Index for the World Trade Center General Responder Cohort

Details

• Personal Author:
  Bello GA ; Crane MA ; Lucchini RG ; Shapiro M ; Teitelbaum SL ; Todd AC
• Description:
  Responders to the 9/11/2001 WTC attacks were exposed to multiple toxic pollutants. Since 2002, the health of the responder cohort has been continuously tracked by the WTC Health Monitoring Program. However, no assessments have been made of frailty, an important health metric given the current average age of the WTC responder cohort (55 years). In this study, we use laboratory test results and other physiological parameters to construct a physiological frailty index (FI-Lab) for this cohort. The study sample comprised responders aged 40 years or older who completed a health monitoring visit at Mount Sinai Center within the past 5 years. For each subject, FI-Lab was computed as the proportion of 20 physiological parameters (lab tests, pulmonary function, and blood pressure) on which the subject had abnormal values. Using negative binomial regression models, we tested FI-Lab's association with the SF-12 wellbeing score and various demographic characteristics. FI-Lab showed strong associations with the physical and mental components of the SF-12 as well as age, race, and smoking status. Using a cutoff of 0.25 to define presence of physiological/preclinical frailty, we found frailty prevalence in the study sample to be approximately 12%. This study demonstrates the feasibility of assessing preclinical frailty in the WTC responder cohort. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Chronic Disease Demography Emergency Responders Lung Occupational Health Race Factors Respiratory System Safety September 11 Terrorist Attacks Smokers

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• Keywords:
  Analytical Models Analytical Processes Chronic Diseases Demographic Characteristics Emergency Responders Hypertension Life Expectancy Pulmonary Function Racial Factors Rescue Workers Smoking Statistical Analysis World Trade Center WTC

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• ISSN:
  1687-7063
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  New Jersey ; New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  2018
• NIOSHTIC Number:
  nn:20051247
• Citation:
  Curr Gerontol Geriatr Res 2018 Feb; 2018:3725926
• Contact Point Address:
  Ghalib A. Bello, PhD, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, Box 1057, New York 10029, NY
• Email:
  ghalib.bello@mssm.edu
• Federal Fiscal Year:
  2018
• Performing Organization:
  State University of New York Stony Brook
• Peer Reviewed:
  True
• Start Date:
  20040715
• Source Full Name:
  Current Gerontology and Geriatrics Research
• End Date:
  20110630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f52281a702799272576ecb5ef11dcfa0e5f919165fe6cf12ef340f25fbf80023d26ef1233126943261b840255b75b3fee2ce005d93d10e29a17351fbcfc81579
• Download URL:
  https://stacks.cdc.gov/view/cdc/211313/cdc_211313_DS1.pdf
• File Type:
  [PDF - 1.56 MB ]