Prenatal Exposure to Persistent Organochlorines and Childhood Obesity in the U.S. Collaborative Perinatal Project

Details

• Alternative Title:
  Environ Health Perspect
• Personal Author:
  Cupul-Uicab, Lea A. ; Klebanoff, Mark A. ; Brock, John W. ; Longnecker, Matthew P.
• Description:
  In some previous studies, prenatal exposure to persistent organochlorines such as 1,1,-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p´-DDE), polychlorinated biphenyls (PCBs), and hexachlorobenzene (HCB) has been associated with higher body mass index (BMI) in children.|Our goal was to evaluate the association of maternal serum levels of β-hexachlorocyclohexane (β-HCH), p,p´-DDE, dichlorodiphenyltrichloroethane (p,p´-DDT), dieldrin, heptachlor epoxide, HCB, trans-nonachlor, oxychlordane, and PCBs with offspring obesity during childhood.|The analysis was based on a subsample of 1,915 children followed until 7 years of age as part of the U.S. Collaborative Perinatal Project (CPP). The CPP enrolled pregnant women in 1959-1965; exposure levels were measured in third-trimester maternal serum that was collected before these organochlorines were banned in the United States. Childhood overweight and obesity were defined using age- and sex-specific cut points for BMI as recommended by the International Obesity Task Force.|Adjusted results did not show clear evidence for an association between organochlorine exposure and obesity; however, a suggestive finding emerged for dieldrin. Compared with those in the lowest quintile (dieldrin, < 0.57 μg/L), odds of obesity were 3.6 (95% CI: 1.3, 10.5) for the fourth and 2.3 (95% CI: 0.8, 7.1) for the highest quintile. Overweight and BMI were unrelated to organochlorine exposure.|In this population with relatively high levels of exposure to organochlorines, no clear associations with obesity or BMI emerged.
• Subjects:
  Body Mass Index Body Weights And Measures Child Child, Preschool Female Humans Hydrocarbons, Chlorinated Infant Logistic Models Male Obesity Pregnancy Prenatal Exposure Delayed Effects Research

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• Source:
  Environ Health Perspect. 2013; 121(9):1103-1109.
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Volume:
  121
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:1bb790e9e93f4228974ec827c9b3837e3231c6ec9bcdde2991f125bd1f0d8eb5
• Download URL:
  https://stacks.cdc.gov/view/cdc/21131/cdc_21131_DS1.pdf
• File Type:
  [PDF - 324.22 KB ]