Drilling and Production Activity Related to Unconventional Gas Development and Severity of Preterm Birth
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2018/03/01
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Description:BACKGROUND: Studies of unconventional gas development (UGD) and preterm birth (PTB) have not presented risk estimates by well development phase or trimester. OBJECTIVE: We examined phase and trimester-specific associations between UGD activity and PTB. METHODS: We conducted a case-control study of women with singleton births in the Barnett Shale area, Texas, from 30 November 2010 to 29 November 2012. We individually age- and race/ethnicity-matched five controls to each PTB case (n=13,328) and truncated controls' time at risk according to the matched case's gestational age. We created phase-specific UGD-activity metrics: a) inverse squared distance-weighted (IDW) count of wells in the drilling phase ≤ 0:5 mi (804.7 meters) of the residence and b) IDW sum of natural gas produced ≤ 0.5 mi of the residence. We also constructed trimester- and gestation-specific metrics. Metrics were categorized as follows: zero wells (reference), first, second, third tertiles of UGD activity. Analyses were repeated by PTB severity: extreme, very, and moderate (<28, 28 to<32, and 32 to <37 completed weeks). Data were analyzed using conditional logistic regression. RESULTS: We found increased odds of PTB in the third tertile of the UGD drilling {odds ratio (OR) = 1.20 [95%confidence interval (CI): 1.06, 1.37]} and UGD-production [OR=1.15 (1.05, 1.26)] metrics. Among women in the third tertile of UGD-production, associations were strongest in trimesters one [OR=1.18 (1.02, 1.37)] and two [OR=1.14 (0.99, 1.31)]. The greatest risk was observed for extremely PTB [third tertile ORs: UGD drilling, 2.00 (1.23, 3.24); UGD production, 1.53 (1.03-2.27)]. CONCLUSIONS: We found evidence of differences in phase- and trimester-specific associations of UGD and PTB and indication of particular risk associated with extremely preterm birth. Future studies should focus on quantifying specific chemical and nonchemical stressors associated with UGD. [Description provided by NIOSH]
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ISSN:0091-6765
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Volume:126
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Issue:3
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NIOSHTIC Number:nn:20051216
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Citation:Environ Health Perspect 2018 Mar; 126(3):037006
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Contact Point Address:K. W. Whitworth, UTHealth School of Public Health, San Antonio Regional Campus, 7411 John Smith Drive, Suite 1100, San Antonio, TX 78229, USA
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Email:Kristina.W.Whitworth@uth.tmc.edu
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Federal Fiscal Year:2018
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Performing Organization:University of Texas Health Science Center, Houston
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Peer Reviewed:True
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Start Date:20050701
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Source Full Name:Environmental Health Perspectives
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End Date:20250630
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Main Document Checksum:urn:sha-512:fb1ee1230f6085701f656aaf4f931e53ded3ebeffa7dd039da8005da70351d00f2c6ab22bffb16e9f9f2eaf90a4cf7eb492fb7a91706eed8dc9a6245a5b40882
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