Exposure-Lag-Response in Longitudinal Studies: Application of Distributed-Lag Nonlinear Models in an Occupational Cohort

Details

• Personal Author:
  Brown DM ; Checkoway, Harvey ; Costello S ; Eisen EA ; Gallagher LE ; Neophytou AM ; Picciotto S
• Description:
  Prolonged exposures can have complex relationships with health outcomes, as timing, duration, and intensity of exposure are all potentially relevant. Summary measures such as cumulative exposure or average intensity of exposure may not fully capture these relationships. We applied penalized and unpenalized distributed lag non-linear models (DLNMs) with flexible exposure-response and lag-response functions in order to examine the association between crystalline silica exposure and mortality from lung cancer and non-malignant respiratory disease in a cohort study of 2,342 California diatomaceous earth workers, followed 1942-2011. We also assessed associations using simple measures of cumulative exposure assuming linear exposure-response and constant lag-response. Measures of association from DLNMs were generally higher than from simpler models. Rate ratios from penalized DLNMs corresponding to average daily exposures of 0.4 mg/m3 during lag years 31-50 prior to the age of observed cases were 1.47 (95% confidence interval (CI) 0.92, 2.35) for lung cancer and 1.80 (95% CI: 1.14, 2.85) for non-malignant respiratory disease. Rate ratios from the simpler models for the same exposure scenario were 1.15 (95% CI: 0.89-1.48) and 1.23 (95% CI: 1.03-1.46) respectively. Longitudinal cohort studies of prolonged exposures and chronic health outcomes should explore methods allowing for flexibility and non-linearities in the exposure-lag-response. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Environmental Exposure Lung Lung Diseases Morbidity Mortality Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Silicon Dioxide

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• Keywords:
  Author Keywords: Chronic Disease Cancer Cohort Studies Crystalline Silica Diatomaceous Earth Distributed Lag Non-linear Models Etiology Exposure-lag-response Exposure Levels Health Effects Longitudinal Cohort Lung Cancer Models Morbidity Rates Mortality Rates Pulmonary System Disorders Respiratory Diseases Respiratory System Disorders Risk Factors Silica

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• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Massachusetts ; OSHA Region 1 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  187
• Issue:
  7
• NIOSHTIC Number:
  nn:20051089
• Citation:
  Am J Epidemiol 2018 Jul; 187(7):1539-1548
• Contact Point Address:
  Dr. Andreas M. Neophytou, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, 50 University Hall #7360, Berkeley, CA 94720-7360
• Email:
  aneophytou@berkeley.edu
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7)
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:48ac4775b911776e7c33ba75b1b2d3bf3c99b36e482fa327e54274f37e45baece96850c35acf005fa3717a8f3ecfc5d3fa31313441a6e29d3873b3b42fa16ace
• Download URL:
  https://stacks.cdc.gov/view/cdc/211215/cdc_211215_DS1.pdf
• File Type:
  [PDF - 615.27 KB ]