Tinnitus and Temporary Hearing Loss Result in Differential Noise-Induced Spatial Reorganization of Brain Activity

Details

• Personal Author:
  Ahmad F ; Apawu AK ; Berkowitz BA ; Ghoddoussi F ; Hali M ; Holt AG ; Muca A ; Standafer E ; Warila J
• Description:
  Loud noise frequently results in hyperacusis or hearing loss (i.e., increased or decreased sensitivity to sound). These conditions are often accompanied by tinnitus (ringing in the ears) and changes in spontaneous neuronal activity (SNA). The ability to differentiate the contributions of hyperacusis and hearing loss to neural correlates of tinnitus has yet to be achieved. Towards this purpose, we used a combination of behavior, electrophysiology, and imaging tools to investigate two models of noise-induced tinnitus (either with temporary hearing loss or with permanent hearing loss). Manganese (Mn2+) uptake was used as a measure of calcium channel function and as an index of SNA. Manganese uptake was examined in vivo with manganese-enhanced magnetic resonance imaging (MEMRI) in key auditory brain regions implicated in tinnitus. Following acoustic trauma, MEMRI, the SNA index, showed evidence of spatially dependent rearrangement of Mn2+ uptake within specific brain nuclei (i.e., reorganization). Reorganization of Mn2+ uptake in the superior olivary complex and cochlear nucleus was dependent upon tinnitus status. However, reorganization of Mn2+ uptake in the inferior colliculus was dependent upon hearing sensitivity. Furthermore, following permanent hearing loss, reduced Mn2+ uptake was observed. Overall, by combining testing for hearing sensitivity, tinnitus, and SNA, our data move forward the possibility of discriminating the contributions of hyperacusis and hearing loss to tinnitus. [Description provided by NIOSH]
• Subjects:
  Behavior Hearing Loss Hearing Loss, Noise-Induced Manganese Noise Noise, Occupational Occupational Health Safety
• Keywords:
  Acoustic Trauma Author Keywords: Acoustic Startle Reflex Brain Electrical Activity Calcium Electrophysiological Effects Gap Detection Hearing Loss Hyperactivity Hyperacusis In Vivo Study Magnetic Resonance Imaging Manganese Compounds Manganese Enhanced MRI MEMRI Models MRI Neuronal Activity Neuroplasticity Noise Induced Hearing Loss Permanent Threshold Shift Temporary Threshold Shift Tinnitus

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• ISSN:
  1863-2653
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  223
• Issue:
  5
• NIOSHTIC Number:
  nn:20051079
• Citation:
  Brain Struct Funct 2018 Jun; 223(5):2343-2360
• Contact Point Address:
  Avril Genene Holt, Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, USA
• Email:
  agholt@med.wayne.edu
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Brain Structure and Function
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8aaf0ed4010ffeda867fd211670473edecc5d4554505ff998005de75cd937d4370918a7bb420761d08b252ba6a43a1652a58d0512f2b0de21dcbe9d400ac3258
• Download URL:
  https://stacks.cdc.gov/view/cdc/211205/cdc_211205_DS1.pdf
• File Type:
  [PDF - 2.09 MB ]