The Need for Non- or Minimally-Invasive Biomonitoring Strategies and the Development of Pharmacokinetic/Pharmacodynamic Models for Quantification

Details

• Personal Author:
  Smith JN ; Timchalk C ; Weber TJ
• Description:
  Advancements in Exposure Science involving the development and deployment of biomarkers of exposure and biological response are anticipated to significantly (and positively) influence health outcomes associated with occupational, environmental and clinical exposure to chemicals/drugs. To achieve this vision, innovative strategies are needed to develop multiplex sensor platforms capable of quantifying individual and mixed exposures (i.e. systemic dose) by measuring biomarkers of dose and biological response in readily obtainable (non-invasive) biofluids. Secondly, the use of saliva (alternative to blood) for biomonitoring coupled with the ability to rapidly analyze multiple samples in real-time offers an innovative opportunity to revolutionize biomonitoring assessments. In this regard, the timing and number of samples taken for biomonitoring will not be limited as is currently the case. In addition, real-time analysis will facilitate identification of work practices or conditions that are contributing to increased exposures and will make possible a more rapid and successful intervention strategy. The initial development and application of computational models for evaluation of saliva/blood analyte concentration at anticipated exposure levels represents an important opportunity to establish the limits of quantification and robustness of multiplex sensor systems by exploiting a unique computational modeling framework. The use of these pharmacokinetic models will also enable prediction of an exposure dose based on the saliva/blood measurement. This novel strategy will result in a more accurate prediction of exposures and, once validated, can be employed to assess dosimetry to a broad range of chemicals in support of biomonitoring and epidemiology studies. [Description provided by NIOSH]
• Subjects:
  Biomarkers Chemistry Environmental Exposure Epidemiology Occupational Health Radiation Dosimeters Safety
• Keywords:
  Author Keywords: Biomarkers Biological Factors Biomonitoring Chemical Properties Computational Modeling Dosimetry Drugs Environmental Exposure Exposure Levels Intervention Models Non-invasive Pharmacodynamics Sampling Sensors

  More +
• ISSN:
  2468-2020
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  28-34
• Volume:
  4
• NIOSHTIC Number:
  nn:20051000
• Citation:
  Curr Opin Toxicol 2017 Jun; 4:28-34
• Contact Point Address:
  Charles Timchalk, Pacific Northwest National Laboratory, Richland, WA 99354
• Email:
  Charles.timchalk@pnnl.gov
• Federal Fiscal Year:
  2017
• Performing Organization:
  Battelle Pacific Northwest Laboratory
• Peer Reviewed:
  True
• Start Date:
  20060901
• Source Full Name:
  Current Opinion in Toxicology
• End Date:
  20170831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1a96fca0dfeba146ac24ddeb2700a003728d7c46975e40360dc5d29fbe88bb54897985d0dc8abb2124603fa9c9c26484c766fad089060f6ca2c00901462d4a37
• Download URL:
  https://stacks.cdc.gov/view/cdc/211145/cdc_211145_DS1.pdf
• File Type:
  [PDF - 1.10 MB ]