An Official American Thoracic Society Workshop Report: Chemical Inhalational Disasters – Biology of Lung Injury, Development of Novel Therapeutics, and Medical Preparedness

Details

• Personal Author:
  Hoyle GW ; Jordt S-E ; Jugg BJ ; Martin JG ; Matalon S ; Patterson SE ; Prezant DJ ; Sciuto AM ; Summerhill EM ; Svendsen ER ; Veress LA ; White CW
• Description:
  This report is based on the proceedings from the Inhalational Lung Injury Workshop jointly sponsored by the American Thoracic Society (ATS) and the National Institutes of Health (NIH) Countermeasures Against Chemical Threats (CounterACT) program on May 21, 2013, in Philadelphia, Pennsylvania. The CounterACT program facilitates research leading to the development of new and improved medical countermeasures for chemical threat agents. The workshop was initiated by the Terrorism and Inhalational Disasters Section of the Environmental, Occupational, and Population Health Assembly of the ATS. Participants included both domestic and international experts in the field, as well as representatives from U.S. governmental funding agencies. The meeting objectives were to (1) provide a forum to review the evidence supporting current standard medical therapies, (2) present updates on our understanding of the epidemiology and underlying pathophysiology of inhalational lung injuries, (3) discuss innovative investigative approaches to further delineating mechanisms of lung injury and identifying new specific therapeutic targets, (4) present promising novel medical countermeasures, (5) facilitate collaborative research efforts, and (6) identify challenges and future directions in the ongoing development, manufacture, and distribution of effective and specific medical countermeasures. Specific inhalational toxins discussed included irritants/pulmonary toxicants (chlorine gas, bromine, and phosgene), vesicants (sulfur mustard), chemical asphyxiants (cyanide), particulates (World Trade Center dust), and respirable nerve agents. [Description provided by NIOSH]
• Subjects:
  Bromides Cyanides Epidemiology Hazardous Substances Irritants Lung Lung Diseases Nervous System Occupational Health Particulate Matter Pathology Phosgene Respiratory System Respiratory Tract Diseases Safety September 11 Terrorist Attacks Sulfur Compounds

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• Keywords:
  Asphyxiants Chlorine Compounds Cyanide Compounds Gases Injuries Neurotoxins Particulates Physiology Pulmonary Effects Pulmonary System Disorders Respiratory Irritants Respiratory System Disorders Sulfur Compounds Toxins World Trade Center WTC

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• ISSN:
  2329-6933
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; New York ; OSHA Region 1 ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  14
• Issue:
  6
• NIOSHTIC Number:
  nn:20050891
• Citation:
  Ann Am Thorac Soc 2017 Jun; 14(6):1060-1072
• Contact Point Address:
  Eleanor M. Summerhill, M.D., Pulmonary and Critical Care Medicine Division, Lahey Hospital and Medical Center, 41 Mall Road, Burlington, MA 01805
• Email:
  eleanor.m.summerhill@lahey.org
• CAS Registry Number:
  Bromine (CAS RN 7726-95-6) ; Chlorine (CAS RN 7782-50-5) ; Phosgene (CAS RN 75-44-5)
• Federal Fiscal Year:
  2017
• Performing Organization:
  New York City Fire Department
• Peer Reviewed:
  True
• Start Date:
  20110701
• Source Full Name:
  Annals of the American Thoracic Society
• End Date:
  20170331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d9be63c65fce530ca8293df9d79fc641889085d8da4fed6089fa6bff1631ed38a968fb2478622186c5abca94f2b01cf5f7496cd12c76731cad73d522be5f67db
• Download URL:
  https://stacks.cdc.gov/view/cdc/211082/cdc_211082_DS1.pdf
• File Type:
  [PDF - 602.09 KB ]