Longitudinal and Cross-Sectional Analyses of Lung Function in Toluene Diisocyanate Production Workers

Details

• Personal Author:
  Carson M ; Cassidy LD ; Collins JJ ; Conner PR ; Doney B ; Molenaar D ; Storey, Eileen ; Wang, Mei Lin
• Description:
  Objective: The aim of this study was to investigate lung function among toluene diisocyanate (TDI) production workers. Methods: One hundred ninety-seven U.S workers performed spirometry from 2006 through 2012. Results were compared within the study cohort and with U.S. population measures. A mixed-effects model assessed factors affecting repeated forced expiratory volume in 1 second (FEV1) measurements. Results: The cohort's mean FEV1 and forced vital capacity (FVC) percent reference values, although greater than 90%, were significantly lower and the prevalence of abnormal spirometry (predominantly restrictive pattern) was significantly higher than in the U.S. population. Differences in lung function among workers with higher cumulative TDI exposure were in the direction of an exposure effect, but not significant. Conclusion: We found little evidence of an adverse effect of TDI exposure on longitudinal spirometry in these workers. The association between TDI exposure and the increasing prevalence of a restrictive pattern needs further exploration. [Description provided by NIOSH]
• Subjects:
  Asthma, Occupational Cohort Studies Health Care Facilities Workforce And Services Isocyanates Lung Occupational Health Respiratory Function Tests Respiratory System Safety
• Keywords:
  Cohort Studies Diisocyanates Longitudinal Study Lung Function Medical Monitoring Occupational Asthma Pulmonary Function Tests Spirometry Surveillance
• ISSN:
  1076-2752
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; New Jersey ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania ; West Virginia ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  59
• NIOSHTIC Number:
  nn:20050801
• Citation:
  J Occup Environ Med 2017 Dec; 59(12S):S28-S35
• Contact Point Address:
  Eileen Storey, MD, MPH, Surveillance Branch, Respiratory Health Division, NIOSH/CDC, 1095 Willowdale Road, MS HG900, Morgantown, WV 26508
• Email:
  EStorey@cdc.gov
• CAS Registry Number:
  Toluene diisocyanate (CAS RN 26471-62-5)
• Federal Fiscal Year:
  2018
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7333b16f438359c4654b465badc5b5b04cca5956e18f04e01e1a8e2b2b88ef22c88c3389b3b52a50e401575f048b321880d94f53d2aeadbb144b0d1e2a63d9bc
• Download URL:
  https://stacks.cdc.gov/view/cdc/211013/cdc_211013_DS1.pdf
• File Type:
  [PDF - 139.69 KB ]