Physical Chemical Properties and Cell Toxicity of Sanding Copper-Treated Lumber

Details

• Personal Author:
  Andrew M ; Castranova, Vincent ; Lee T ; McKinney W ; Mercer RR ; Qi C ; Qian Y ; Shaffer J ; Sisler JD ; Thomas T
• Description:
  To protect against decay and fungal invasion into the wood, the micronized copper, copper carbonate particles, has been applied in the wood treatment in recent years; however, there is little information on the health risk associated with sanding micronized copper- treated lumber. In this study, wood dust from the sanding of micronized copper azole -treated lumber (MCA) was compared to sanding dust from solubilized copper azole-treated wood (CA-C) and untreated yellow pine (UYP). The test found that sanding MCA released a much higher concentration of nanoparticles than sanding CA-C and UYP, and the particles between about 0.4¦µm to 2¦µm from sanding MCA had the highest percentage of copper. The percentage of copper in the airborne dust from sanding CA-C had a weak dependency on particle size and was lower than that from sanding MCA. Nanoparticles were seen in the MCA PM2.5 particles, while none were detected in the UYP or CA-C. Inductively coupled plasma mass spectrometry (ICP-MS) analysis found that the bulk lumber for MCA and CA-C had relatively equal copper content; however, the PM2.5 particles from sanding the MCA had a higher copper concentration when compared to the PM2.5 particles from sanding UYP or CA-C. The cellular toxicity assays show that exposure of RAW 264.7 macrophages (RAW) to MCA and CA-C wood dust suspensions did not induce cellular toxicity even at the concentration of 200¦µg PM2.5 wood dust/mL. Since the copper from the treated wood dust can leach into the wood dust supernatant, the supernatants of MCA, CA-C and UYP wood dusts were subjected to the cellular toxicity assays. The data showed that at the higher concentrations of copper (= 5¦µg/ml), both MCA and CA-C supernatants induced cellular toxicity. This study suggests that sanding MCA-treated lumber releases copper nanoparticles and both the MCA and CA-C-treated lumber can release copper, which are potentially related to the observed in vitro toxicity. [Description provided by NIOSH]
• Subjects:
  Chemistry Copper Dust Fungi Hazardous Substances Occupational Health Particulate Matter Safety Wood
• Keywords:
  Author Keywords: Sanding Chemical Properties Copper Compounds Copper Dust Lumber Mass Spectrometry Micronized Copper Nanoparticles Nanotechnology Particulate Dust Particulates Physical Chemical Properties Physical Properties Toxins Treated Wood

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• ISSN:
  1545-9624
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Ohio ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  311-321
• Volume:
  15
• Issue:
  4
• NIOSHTIC Number:
  nn:20050762
• Citation:
  J Occup Environ Hyg 2018 Apr; 15(4):311-321
• Contact Point Address:
  Yong Qian, NIOSH/HELD/PPRB, 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  yaq2@cdc.gov
• CAS Registry Number:
  Copper (CAS RN 7440-50-8)
• Federal Fiscal Year:
  2018
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational and Environmental Hygiene
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a41d9c6a278a501162c507a5c9a3217181e0cfa8ac17c12f40a4e5095274ea354fb524df2fc781db31da87592868390fd26adfbd8f81488744f7e98bb0fb69d7
• Download URL:
  https://stacks.cdc.gov/view/cdc/210985/cdc_210985_DS1.pdf
• File Type:
  [PDF - 1.18 MB ]