Details:

Alternative Title:
PLoS One
Personal Author:
Liao, Qiaohong ; Bai, Tian ; Zhou, Lei ; Vong, Sirenda ; Guo, Junqiao ; ... More +
Liao, Qiaohong ; Bai, Tian ; Zhou, Lei ; Vong, Sirenda ; Guo, Junqiao ; Lv, Wei ; Dong, Libo ; Xiang, Nijuan ; Li, Zi ; Huai, Yang ; Zhou, Jianfang ; Li, Xiaodan ; Chen, Ray Y. ; Xu, Zhen ; Uyeki, Timothy M. ; Shu, Yuelong ; Yu, Hongjie Less -
Description:
To assess the extent of highly pathogenic avian influenza (HPAI) A (H5N1) virus transmission, we conducted sero-epidemiologic studies among close contacts exposed to H5N1 cases in mainland China during 2005-2008. Blood specimens were collected from 87 household members and 332 social contacts of 23 H5N1 index cases for HPAI H5N1 serological testing by modified horse red-blood-cell hemagglutinin inhibition and microneutralization assays. All participants were interviewed with a standardized questionnaire to collect information about the use of personal protective equipment, illness symptoms, exposure to an H5N1 case during the infectious period, and poultry exposures. Two (2.3%) household contacts tested positive for HPAI H5N1 virus antibody, and all social contacts tested negative. Both seropositive cases had prolonged, unprotected, close contact with a different H5N1 index case, including days of bed-care or sleeping together during the index case's infectious period, and did not develop any illness. None of the 419 close contacts used appropriate personal protective equipment including 17% who reported providing bedside care or having physical contact with an H5N1 case for at least 12 hours. Our findings suggest that HPAI H5N1 viruses that circulated among poultry in mainland China from 2005-2008 were not easily transmitted to close contacts of H5N1 cases.
Subjects:
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Adolescent Adult Antibodies, Viral Child Child, Preschool Female Humans Influenza, Human Influenza A Virus, H5N1 Subtype Male Middle Aged Population Surveillance Research Article Seroepidemiologic Studies Young Adult
Source:
PLoS One. 2013; 8(8).
Document Type:
Journal Article
Funding:
U19 AI51915/AI/NIAID NIH HHS/United States
Place as Subject:
China
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:db2e6aec56626650364d038bef8d2bf8ea77411b4cf5c543fee6c785870eb4a7
Download URL:
https://stacks.cdc.gov/view/cdc/21098/cdc_21098_DS1.pdf
File Type:

Supporting Files

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