Cardiometabolic Profiles of Adolescents and Young Adults Exposed to the World Trade Center Disaster

Details

• Personal Author:
  Attina TM ; Burdine LK ; Chemtob C ; Gilbert J ; Han X ; Koshy TT ; Marmor M ; Shao Y ; Trasande L ; Urbina EM
• Description:
  Background and objective: Few studies have examined the possible cardiometabolic consequences of World Trade Center-related exposures on children who lived and/or attended school near the disaster site. Our objective was to compare cardiometabolic profiles of participants in the World Trade Center Health Registry (WTCHR) with a matched comparison group. Methods: We evaluated WTCHR enrollees who resided in New York City and were born between September 11, 1993 and September 10, 2001, and a matched comparison group. We assessed exposure to dust cloud, home dust, as well as traumatic exposure, and associations with blood pressure, arterial wall stiffness, body mass index (BMI), total cholesterol, triglycerides, HDL, and LDL. Results: A total of 402 participants completed the study, 222 in the comparison group and 180 in the WTCHR group. In multivariable regression analysis, after adjusting for relevant confounders we detected a weak association between participation in the WTCHR group and lower BMI (-1.12 kg/m2, 95% CI -2.11, -0.12; p = 0.03), which became non-significant after adjusting for multiple comparisons. With respect to traumatic and psychosocial exposures, the only association that persisted in our multivariable model, below our predefined level of significance, was between post-traumatic stress disorder and higher BMI (2.06 kg/m2, 95% CI 0.37, 3.74; p = 0.02). Conclusions: Our findings do not support an association between self-reported exposures to the WTC disaster and adverse cardiometabolic profile. However, further longitudinal studies may better inform the full extent of WTCrelated conditions associated with exposure to the disaster. [Description provided by NIOSH]
• Subjects:
  Adolescent Aging Cardiovascular System Dust Energy Metabolism Environmental Exposure Men Mental Health Occupational Health Risk Assessment Risk Factors Safety September 11 Terrorist Attacks Women

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• Keywords:
  Adolescents Age Groups Author Keywords: World Trade Center Disaster Blood Pressure BMI Body Mass Index Cardiac Function Cardiometabolic Effects Children Dust Exposure Dusts Exposure Levels Humans Metabolic Effects Post-traumatic Stress Disorder Psychological Effects Psychology Psychosocial Factors PTSD Regression Analysis Risk Factors Traumatic Exposure Traumatic Injuries World Trade Center WTC

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• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; Ohio ; OSHA Region 2 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  107-114
• Volume:
  160
• NIOSHTIC Number:
  nn:20050708
• Citation:
  Environ Res 2018 Jan; 160:107-114
• Contact Point Address:
  Leonardo Trasande, Department of Pediatrics, New York University School of Medicine, 403 East 34th Street Rm 115, New York, NY 10016
• Email:
  leonardo.trasande@nyumc.org
• Federal Fiscal Year:
  2018
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20130701
• Source Full Name:
  Environmental Research
• End Date:
  20170630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e197a0c3bf23742a30c7d0d85b5a08634592ad9a84cec8df2e6be3b12f9ed59384ee263e11ce7c406ef3305bc5af1844188ceac3a7ad3a430adced7283d1f6f9
• Download URL:
  https://stacks.cdc.gov/view/cdc/210949/cdc_210949_DS1.pdf
• File Type:
  [PDF - 518.22 KB ]