TRP Channels and Traffic-Related Environmental Pollution-Induced Pulmonary Disease

Details

• Personal Author:
  Akopian AN ; Brooks EG ; Fanick ER
• Description:
  Environmental pollutant exposures are major risk factors for adverse health outcomes, with increased morbidity and mortality in humans. Diesel exhaust (DE) is one of the major harmful components of traffic-related air pollution. Exposure to DE affects several physiological systems, including the airways, and pulmonary diseases are increased in highly populated urban areas. Hence, there are urgent needs to (1) create newer and lesser polluting fuels, (2) improve exhaust aftertreatments and reduce emissions, and (3) understand mechanisms of actions for toxic effects of both conventional and cleaner diesel fuels on the lungs. These steps could aid the development of diagnostics and interventions to prevent the negative impact of traffic-related air pollution on the pulmonary system. Exhaust from conventional, and to a lesser extent, clean fuels, contains particulate matter (PM) and more than 400 additional chemical constituents. The major toxic constituents are nitrogen oxides (NOx) and polycyclic aromatic hydrocarbons (PAHs). PM and PAHs could potentially act via transient receptor potential (TRP) channels. In this review, we will first discuss the associations between DE from conventional as well as clean fuel technologies and acute and chronic airway inflammation. We will then review possible activation and/or potentiation of TRP vanilloid type 1 (TRPV1) and ankyrin 1 (TRPA1) channels by PM and PAHs. Finally, we will discuss and summarize recent findings on the mechanisms whereby TRPs could control the link between DE and airway inflammation, which is a primary determinant leading to pulmonary disease. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution Asthma Asthma, Occupational Automobiles Environmental Exposure Environmental Pollution Fuel Oils Hazardous Substances Hydrocarbons Lung Lung Diseases Morbidity Mortality Occupational Health Particulate Matter Polycyclic Aromatic Hydrocarbons Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety

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• Keywords:
  Acute Lung Injury Air Pollutants Air Pollution Author Keywords: TRPV1 Clean Diesel DEP Diesel Exhaust Diesel Exhaust Particles Emission Sources Environmental Pollution Exposure Levels Fuels Hazards Health Effects Health Hazards Morbidity Rates Mortality Rates Motor Vehicles Nitrogen Oxides PAHs Particulates Physiological Effects Polycyclic Aromatic Hydrocarbons Pulmonary System Pulmonary System Disorders Respiratory System Disorders Risk Factors Toxic Effects TRPA1

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• ISSN:
  1863-2297
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  331-338
• Volume:
  38
• Issue:
  3
• NIOSHTIC Number:
  nn:20050608
• Citation:
  Semin Immunopathol 2016 May; 38(3):331-338
• Contact Point Address:
  Edward G. Brooks, Center for Airway Inflammation Research, UT Health Science Center at San Antonio, 8403 Floyd Curl Drive, STRF Microbiology MC 8259, San Antonio, TX 78229
• Email:
  brookse@uthscsa.edu
• Federal Fiscal Year:
  2016
• Performing Organization:
  University of Texas Health Science Center, Houston
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Seminars in Immunopathology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9a669aa3e9e5286bc36d4cbfa31355a52c690e553efa62090002138791e140f55a479843f3488ce11a6a36433af0fa25404e6a90ebdd958887b69e2cab5d05c1
• Download URL:
  https://stacks.cdc.gov/view/cdc/210882/cdc_210882_DS1.pdf
• File Type:
  [PDF - 423.27 KB ]