Association of MRI T1 Relaxation Time with Neuropsychological Test Performance in Manganese-Exposed Welders

Details

• Personal Author:
  Adams SW ; Bowler RM ; Dharmadhikari S ; Dydak U ; Ma RE ; Snyder SA ; Ward EJ ; Wright CW ; Yeh C-L ; Zauber SE
• Description:
  This study examines the results of neuropsychological testing of 26 active welders and 17 similar controls and their relationship to welders' shortened MRI T1 relaxation time, indicative of increased brain manganese (Mn) accumulation. Welders were exposed to Mn for an average duration of 12.25 years to average levels of Mn in air of 0.11+/-0.05mg/m3. Welders scored significantly worse than controls on Fruit Naming and the Parallel Lines test of graphomotor tremor. Welders had shorter MRI T1 relaxation times than controls in the globus pallidus, substantia nigra, caudate nucleus, and the anterior prefrontal lobe. 63% of the variation in MRI T1 relaxation times was accounted for by exposure group. In welders, lower relaxation times in the caudate nucleus and substantia nigra were associated with lower neuropsychological test performance on tests of verbal fluency (Fruit Naming), verbal learning, memory, and perseveration (WHO-UCLA AVLT). Results indicate that verbal function may be one of the first cognitive domains affected by brain Mn deposition in welders as reflected by MRI T1 relaxation times. [Description provided by NIOSH]
• Subjects:
  Nervous System Occupational Exposure Occupational Health Safety Welding
• Keywords:
  Brain Function Chronic Exposure Cognitive Function Magnetic Resonance Imaging Manganese Compounds MRI Neurological Reactions Welders
• ISSN:
  0161-813X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Georgia ; Indiana ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  19-29
• Volume:
  64
• NIOSHTIC Number:
  nn:20050534
• Citation:
  Neurotoxicology 2018 Jan; 64:19-29
• Contact Point Address:
  U. Dydak, School of Health Sciences, Purdue University, 550 Stadium Mall Drive, West Lafayette, IN 47907, USA
• Email:
  udydak@purdue.edu
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2018
• Performing Organization:
  Purdue University, West Lafayette, Indiana
• Peer Reviewed:
  True
• Start Date:
  20010701
• Source Full Name:
  Neurotoxicology
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:87d6379c27b0856e64a8964c003e4380e81432df17eb7b91a69e26f213e1a7eb15875d6ae49ca4b4f3fe2f06ed03a775b190c1fd966fb0520acb0e51ab42fc55
• Download URL:
  https://stacks.cdc.gov/view/cdc/210842/cdc_210842_DS1.pdf
• File Type:
  [PDF - 802.09 KB ]