Occupational Exposures and Subclinical Interstitial Lung Disease: The MESA (Multi-Ethnic Study of Atherosclerosis) Air and Lung Studies

Details

• Personal Author:
  Barr RG ; Doney BC ; Hoffman EA ; Hopper LG ; Kaufman JD ; Kawut SM ; Lederer DJ ; Podolanczuk AJ ; Raghu G ; Sack CS ; Seixas, Noah S. ; Vedal S
• Description:
  Rationale: The impact of a broad range of occupational exposures on subclinical interstitial lung disease (ILD) has not been studied. Objectives: To determine whether occupational exposures to vapors, gas, dust, and fumes (VGDF) are associated with high-attenuation areas (HAA) and interstitial lung abnormalities (ILA), which are quantitative and qualitative computed tomography (CT)-based measurements of subclinical ILD, respectively. Methods: We performed analyses of participants enrolled in MESA (Multi-Ethnic Study of Atherosclerosis), a population-based cohort aged 45-84 years at recruitment. HAA was measured at baseline and on serial cardiac CT scans in 5,702 participants. ILA was ascertained in a subset of 2,312 participants who underwent full-lung CT scanning at 10-year follow-up. Occupational exposures were assessed by self-reported VGDF exposure and by job-exposure matrix (JEM). Linear mixed models and logistic regression were used to determine whether occupational exposures were associated with log-transformed HAA and ILA. Models were adjusted for age, sex, race/ethnicity, education, employment status, tobacco use, and scanner technology. Measurements and Main Results: Each JEM score increment in VGDF exposure was associated with 2.64% greater HAA (95% confidence interval [CI], 1.23-4.19%). Self-reported vapors/gas exposure was associated with an increased odds of ILA among those currently employed (1.76-fold; 95% CI, 1.09-2.84) and those less than 65 years old (1.97-fold; 95% CI, 1.16-3.35). There was no consistent evidence that occupational exposures were associated with progression of HAA over the follow-up period. Conclusions: JEM-assigned and self-reported exposures to VGDF were associated with measurements of subclinical ILD in community-dwelling adults. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Cohort Studies Dust Epidemiology Lung Diseases Occupational Exposure Occupational Health Respiratory Tract Diseases Safety Solvents
• Keywords:
  Author Keywords: Epidemiology Cohort Studies Community-based Study Community Based Dusts Fumes Gases Interstitial Lung Disease Lung Disease Occupational Exposure Occupational Exposures Subclinical Vapors

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• ISSN:
  1073-449X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Iowa ; New York ; OSHA Region 10 ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 7 ; Pennsylvania ; Washington ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  196
• Issue:
  8
• NIOSHTIC Number:
  nn:20050511
• Citation:
  Am J Respir Crit Care Med 2017 Oct; 196(8):1031-1039
• Contact Point Address:
  David J. Lederer, M.D., M.S., Department of Medicine, Division of Pulmonary, Critical Care, Allergy, Columbia University Medical Center, 161 Fort Washington Avenue, Room 3-321A, New York, NY 10032
• Email:
  dl427@cumc.columbia.edu
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8244f45379cbe65c40dd2b18c9fa6a9c989b58b6072181d0e15e5cba3852046959c9a9dc63da5b2738d25ec80624417e2fc11419171f0e1a5e83829b6c5c6757
• Download URL:
  https://stacks.cdc.gov/view/cdc/210828/cdc_210828_DS1.pdf
• File Type:
  [PDF - 558.00 KB ]