Inflammaging and the Age-Specific Responsiveness to Stretch-Shortening Contractions

Details

• Personal Author:
  Baker BA ; Rader EP
• Description:
  With aging, muscle injury from rapid, continuous stretch-shortening contractions (SSC) is prolonged, and maladaptation to moderate-velocity, intermittent SSC is more common. We hypothesize that high baseline levels of inflammatory signaling and oxidative stress may underlie these outcomes, whereas careful modulation of high-intensity SSC training design resets basal conditions and permits muscle adaptation to SSC. Key Points: 1. With aging, chronic levels of inflammatory signaling and oxidative stress increase. 2. Accompanying this environment is amuted inflammatory response and slow recovery after an acute exposure to rapid, continuous SSC (comparable to sprint training) and exacerbated weakness from frequent exposure to moderate-velocity, intermittent SSC (comparable to resistance training). 3. Decreasing exposure frequency (e.g., 3 to 2 d per wk) of moderate velocity intermittent SSC improves lipid peroxidation levels and muscle performance. 4. High-activation SSC training with restrained training frequency is a potential intervention to restore muscle to a younger phenotype. [Description provided by NIOSH]
• Subjects:
  Aging Immune System Lipids Musculoskeletal System Occupational Health Safety
• Keywords:
  Activity Levels Author Keywords: Stretch-shortening Contraction Training Chronic Inflammation Cytokines Dynamometer Immune System Lipid Peroxidation Muscle Physiology Muscles Oxidative Stress Physical Exercise Resistance Training

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• ISSN:
  0091-6331
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  195-200
• Volume:
  45
• Issue:
  4
• NIOSHTIC Number:
  nn:20050396
• Citation:
  Exerc Sport Sci Rev 2017 Oct; 45(4):195-200
• Contact Point Address:
  Brent A. Baker, Ph.D., ATC., CDC/NIOSH/HELD/TMBB/SMART, MS 3027, 1095 Willowdale Rd, Morgantown,WV 26505
• Email:
  BWB3@cdc.gov
• Federal Fiscal Year:
  2018
• Peer Reviewed:
  True
• Source Full Name:
  Exercise and Sport Sciences Reviews
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5b8f354c6ddd854363cf6be81cea5c4e97b90875f60af6dee3dcca3618dfabede26cac9a32aa32b857492d70a9fd93716d8c2676395054c7fa4e718e1af08d19
• Download URL:
  https://stacks.cdc.gov/view/cdc/210763/cdc_210763_DS1.pdf
• File Type:
  [PDF - 474.26 KB ]