Allergenicity to Cannabis sativa L. and Methods to Assess Personal Exposure

Details

• Personal Author:
  Beezhold, Donald H. ; Green, Brett J. ; Nayak, Ajay P. ; Sussman G
• Description:
  Cannabis sativa, commonly referred to as marijuana, is popularly recognized as a medicinal and recreational drug. Although the legal status of the plant and its derivatives has been debated in numerous social and legal forums, very little is known about the immunological effects following personal and more recently, occupational exposure. Current studies have shown that direct handling and consumption of C. sativa and its derivatives can elicit allergic reactions and in very rare cases, life-threatening anaphylaxis. Initially, Delta9-THC and cannabinol were suggested to be the potential allergic sensitizers; however, recent reports have demonstrated that allergic reactions to C. sativa may be driven by type I hypersensitivity mechanisms. In this chapter, we will examine the scenarios and routes of exposure to C. sativa that may result in allergic sensitization and provide insights into the key allergic determinants. Finally, the methodological challenges associated with studying the plant and the biotechnological advances in exposure assessment will be additionally discussed. [Description provided by NIOSH]
• Subjects:
  Cannabis Drug Therapy Environmental Exposure Hypersensitivity Immune System Occupational Exposure Occupational Health Respiratory System Safety Substance-Related Disorders
• Keywords:
  Allergens Allergic Reactions Anaphylactic Shock Drugs Drug Therapy Environmental Exposure Exposure Assessment Health Effects Immune Reaction Inhalation Manual Materials Handling Marijuana Marijuana Smoke Occupational Exposure Occupational Health Plants Plant Substances Psychotropic Drugs Sensitization Smoke Inhalation Substance Abuse

  More +
• ISBN:
  9783319545639
• Publisher:
  Springer International Publishing
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  Mississippi ; OSHA Region 3 ; OSHA Region 4 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  263-284
• NIOSHTIC Number:
  nn:20050367
• Citation:
  Cannabis sativa L.- Botany and Biotechnology. Chandra S, Lata H, ElSohly MA, eds. Cham, Switzerland: Springer International Publishing, 2017 May; :263-284
• Contact Point Address:
  A. P. Nayak, Thomas Jefferson University, 1020 Locust Street, Jefferson Alumni Hall, Suite 543, Philadelphia, PA 19107, USA
• Email:
  Ajay.Nayak@jefferson.edu
• CAS Registry Number:
  Tetrahydrocannabinol (CAS RN 1972-08-3)
• Editor(s):
  Chandra S; Lata H; ElSohly MA
• Federal Fiscal Year:
  2017
• Peer Reviewed:
  True
• Source Full Name:
  Cannabis sativa L.- Botany and Biotechnology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a31a8ebfe89fc9410b2c9a8642660ab8212e9e8802423aa6a5bdda6023e91032f5e32af9ec3e9d3fd4b6600e2a3ff4470bbba1f42300215079fa34169ccde0ec
• Download URL:
  https://stacks.cdc.gov/view/cdc/210744/cdc_210744_DS1.pdf
• File Type:
  [PDF - 647.94 KB ]