Is Trimellitic Anhydride Skin Testing a Sufficient Screening Tool for Selectively Identifying TMA-Exposed Workers with TMA-Specific Serum IgE Antibodies?

Details

• Personal Author:
  Bernstein JA ; Ghosh D ; Levin L ; Sublett WJ ; Wells H
• Description:
  OBJECTIVE: Trimellitic anhydride (TMA) can elicit specific IgE-mediated immune responses leading to asthma. This single-blinded study investigated the ability of TMA skin testing to identify workers with TMA-serum specific IgE antibodies. METHODS: Forty TMA-exposed workers who were previously screened for the presence of TMA-IgG and/or IgE serum specific antibodies were skin tested to a TMA-human serum albumin reagent by nurses blinded to their antibody responses. RESULTS: Findings from skin-prick tests were positive in 8 of 11 workers with TMA-serum specific IgE antibodies. Intracutaneous testing, performed only on skin prick testing-negative workers, was positive in two additional workers with TMA-serum specific IgE antibodies. A significant correlation was found between serum and skin test dilutions eliciting positive responses (p = 0.87, P < 0.05; n = 11). CONCLUSIONS: TMA skin testing provides an alternative and potentially more practical method for monitoring TMA-exposed workers for developing IgE sensitization. [Description provided by NIOSH]
• Subjects:
  Antibodies Asthma Environmental Exposure Immune System Men Occupational Health Phthalic Anhydrides Respiratory System Respiratory Tract Diseases Safety Skin Women

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• Keywords:
  Bronchial Asthma Exposure Levels Humans Immune Reaction Immunoglobulins Immunology Monitoring Systems Skin Tests Surveillance Trimellitic Anhydride
• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  53
• Issue:
  10
• NIOSHTIC Number:
  nn:20050264
• Citation:
  J Occup Environ Med 2011 Oct; 53(10):1122-1127
• Contact Point Address:
  Jonathan A. Bernstein, MD, University of Cincinnati, 231 Albert Sabin Way, ML 563, Cincinnati, OH 45267
• Email:
  Jonathan.Bernstein@uc.edu
• Federal Fiscal Year:
  2012
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:71263d727e8e47fa8f2bd9d4fb693dff5daf426dfb464b2773d1a15341a1bb8ba96be6c39a6f0742a8df2c1d56a406750064d37d3f01856b03225dec5fb93164
• Download URL:
  https://stacks.cdc.gov/view/cdc/210686/cdc_210686_DS1.pdf
• File Type:
  [PDF - 222.06 KB ]