Mesothelioma Associated with Commercial Use of Vermiculite Containing Libby Amphibole

Details

• Personal Author:
  Adjei S ; Borton E ; Dunning KK ; Hilbert T ; Kapil V ; Lemasters GK ; Levin L ; Lockey, James E. ; Rice C ; Rohs AM
• Description:
  OBJECTIVES: To describe asbestos-related mortality among manufacturing workers who expanded and processed Libby vermiculite that contained amphibole fiber. METHODS: Standardized mortality ratio was calculated for 465 white male workers 31 years after last Libby vermiculite exposure. RESULTS: Two workers died from mesothelioma, resulting in a significantly increased standardized mortality ratio of 10.5 (95% confidence interval, 1.3 to 38.0). These workers were in the upper 10th percentile of cumulative fiber exposure, that is, 43.80 and 47.23 fiber-years/cm, respectively. One additional worker with cumulative fiber exposure of 5.73 fiber-years/cm developed mesothelioma but is not deceased. There were no other significantly increased standardized mortality ratios. CONCLUSIONS: Workers expanding and processing Libby vermiculite in a manufacturing setting demonstrated an increased risk for the development of mesothelioma following exposure to the amphibole fiber contained within this vermiculite ore source. [Description provided by NIOSH]
• Subjects:
  Aging Asbestos Chemistry Environmental Exposure Inorganic Chemicals Men Morbidity Mortality Neoplasms Occupational Health Particulate Matter Race Factors Risk Assessment Risk Factors Safety

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• Keywords:
  Age Groups Chemical Properties Chemicals Exposure Levels Fibers Fibrous Bodies Health Effects Humans Mesothelioma Morbidity Rates Mortality Rates Racial Factors Risk Factors Statistical Analysis Vermiculite

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• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  54
• Issue:
  11
• NIOSHTIC Number:
  nn:20050214
• Citation:
  J Occup Environ Med 2012 Nov; 54(11):1359-1363
• Contact Point Address:
  James E. Lockey, MD, MS, Departments of Environmental Health, University of Cincinnati College of Medicine, 3223 Eden Ave, ML 0056, Cincinnati, OH 45267
• Email:
  james.lockey@uc.edu
• CAS Registry Number:
  Amphibole-group minerals (CAS RN 1318-09-8) ; Asbestos (CAS RN 1332-21-4)
• Federal Fiscal Year:
  2013
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:16bf371086f91f047cbbdb5adc43c4b18300983b6deeac6eafdcdac5338bad442ac165cbecddf6817da8fc6a6ff7a9328b22be9f1c0fce46b0cd05a7a3bd43ce
• Download URL:
  https://stacks.cdc.gov/view/cdc/210655/cdc_210655_DS1.pdf
• File Type:
  [PDF - 93.18 KB ]