Details:

Alternative Title:
PLoS One
Personal Author:
Moss, Alastair J. ; Gaughran, Fiona P. ; Karasu, Aliyye ; Gilbert, Anthony S. ; Mann, Alex J. ; ... More +
Moss, Alastair J. ; Gaughran, Fiona P. ; Karasu, Aliyye ; Gilbert, Anthony S. ; Mann, Alex J. ; Gelder, Colin M. ; Oxford, John S. ; Stephens, Henry A. ; Lambkin-Williams, Rob ; Less -
Description:
Influenza is a major cause of morbidity and mortality. Despite vaccination, many elderly recipients do not develop a protective antibody response. To determine whether Human Leukocyte Antigen (HLA) alleles modulate seroprotection to influenza, a cohort of HLA class II-typed high-risk vaccine recipients was investigated. Haemagglutinin inhibition (HAI) titres were measured 14-40 days post-subunit vaccination. Seroprotection was defined as HAI titres reaching 40 or greater for all three vaccine strains. HLA-DRB1*04∶01 and HLA-DPB1*04∶01 alleles were detected at higher frequencies in seroprotected compared with non-seroprotected individuals. Thus, the presence of certain HLA class II alleles may determine the magnitude of antibody responses to influenza vaccination.
Subject:
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Biology
Medicine
Research Article

Source:
PLoS One. 2013; 8(8).
Document Type:
Journal Article ;
Collection(s):
CDC Public Access
Main Document Checksum:
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urn:sha256:cb5ede052f895f0c320bae9bd0f251713cf6635751beb766a393c5b1b04f1693
File Type:

Supporting Files

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  	pone.0071376.nxml	txt
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