Correlation between Human Leukocyte Antigen Class II Alleles and HAI Titers Detected Post-Influenza Vaccination

Moss, Alastair J.; Gaughran, Fiona P.; Karasu, Aliyye; Gilbert, Anthony S.; Mann, Alex J.; Gelder, Colin M.; Oxford, John S.; Stephens, Henry A.; Lambkin-Williams, Rob

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Correlation between Human Leukocyte Antigen Class II Alleles and HAI Titers Detected Post-Influenza Vaccination

Published Date:

Aug 09 2013

Source:

PLoS One. 2013; 8(8).

[PDF-82.05 KB]

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Alternative Title:

PLoS One

Personal Author:

Moss, Alastair J. ; Gaughran, Fiona P. ; Karasu, Aliyye ; Gilbert, Anthony S. ; Mann, Alex J. ; ... More ▼

Description:

Influenza is a major cause of morbidity and mortality. Despite vaccination, many elderly recipients do not develop a protective antibody response. To determine whether Human Leukocyte Antigen (HLA) alleles modulate seroprotection to influenza, a cohort of HLA class II-typed high-risk vaccine recipients was investigated. Haemagglutinin inhibition (HAI) titres were measured 14-40 days post-subunit vaccination. Seroprotection was defined as HAI titres reaching 40 or greater for all three vaccine strains. HLA-DRB1*04∶01 and HLA-DPB1*04∶01 alleles were detected at higher frequencies in seroprotected compared with non-seroprotected individuals. Thus, the presence of certain HLA class II alleles may determine the magnitude of antibody responses to influenza vaccination.

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Document Type:

Journal Article

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CDC Public Access

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