Correlation between Human Leukocyte Antigen Class II Alleles and HAI Titers Detected Post-Influenza Vaccination

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Moss, Alastair J. ; Gaughran, Fiona P. ; Karasu, Aliyye ; Gilbert, Anthony S. ; Mann, Alex J. ; Gelder, Colin M. ; Oxford, John S. ; Stephens, Henry A. ; Lambkin-Williams, Rob
• Description:
  Influenza is a major cause of morbidity and mortality. Despite vaccination, many elderly recipients do not develop a protective antibody response. To determine whether Human Leukocyte Antigen (HLA) alleles modulate seroprotection to influenza, a cohort of HLA class II-typed high-risk vaccine recipients was investigated. Haemagglutinin inhibition (HAI) titres were measured 14-40 days post-subunit vaccination. Seroprotection was defined as HAI titres reaching 40 or greater for all three vaccine strains. HLA-DRB1*04∶01 and HLA-DPB1*04∶01 alleles were detected at higher frequencies in seroprotected compared with non-seroprotected individuals. Thus, the presence of certain HLA class II alleles may determine the magnitude of antibody responses to influenza vaccination.
• Subjects:
  Biology Medicine Research Article
• Source:
  PLoS One. 2013; 8(8).
• Document Type:
  Journal Article
• Volume:
  8
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:cb5ede052f895f0c320bae9bd0f251713cf6635751beb766a393c5b1b04f1693
• Download URL:
  https://stacks.cdc.gov/view/cdc/21058/cdc_21058_DS1.pdf
• File Type:
  [PDF - 82.05 KB ]