Correlation between Human Leukocyte Antigen Class II Alleles and HAI Titers Detected Post-Influenza Vaccination

Moss, Alastair J.; Gaughran, Fiona P.; Karasu, Aliyye; Gilbert, Anthony S.; Mann, Alex J.; Gelder, Colin M.; Oxford, John S.; Stephens, Henry A.; Lambkin-Williams, Rob

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Correlation between Human Leukocyte Antigen Class II Alleles and HAI Titers Detected Post-Influenza Vaccination

Published Date:

Aug 09 2013

Source:

PLoS One. 2013; 8(8).

[PDF-82.05 KB]

Details:

Personal Authors:

Moss, Alastair J. ; Gaughran, Fiona P. ; Karasu, Aliyye ; Gilbert, Anthony S. ; Mann, Alex J. ; ... More ▼

Keywords:

[+]

Description:

Influenza is a major cause of morbidity and mortality. Despite vaccination, many elderly recipients do not develop a protective antibody response. To determine whether Human Leukocyte Antigen (HLA) alleles modulate seroprotection to influenza, a cohort of HLA class II-typed high-risk vaccine recipients was investigated. Haemagglutinin inhibition (HAI) titres were measured 14-40 days post-subunit vaccination. Seroprotection was defined as HAI titres reaching 40 or greater for all three vaccine strains. HLA-DRB1*04∶01 and HLA-DPB1*04∶01 alleles were detected at higher frequencies in seroprotected compared with non-seroprotected individuals. Thus, the presence of certain HLA class II alleles may determine the magnitude of antibody responses to influenza vaccination.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Supporting Files:

license.txt	text/plain
pone.0071376.nxml	text/plain
pone.0071376.t001.gif	image/gif
pone.0071376.t001.jpg	image/jpeg
pone.0071376.t002.gif	image/gif
pone.0071376.t002.jpg	image/jpeg
pone.0071376.t003.gif	image/gif
pone.0071376.t003.jpg	image/jpeg

No Related Documents.

You May Also Like:

Molecular signatures of antibody responses derived from a systems biological study of 5 human vaccines

Personal Author:

Li, Shuzhao; Rouphael, Nadine; Duraisingham, Sai; Romero-Steiner, Sandra; Presnell, Scott; Davis, Carl; Schmidt, Daniel S; Johnson, Scott E; Milton, Andrea; Rajam, Gowrisankar; Kasturi, Sudhir; Carlone, George M; Quinn, Charlie; Chaussabel, Damien; Palucka, A Karolina; Mulligan, Mark J; Ahmed, Rafi; Stephens, David S; Nakaya, Helder I; Pulendran, Bali;

Published:

Dec 15 2013

Source:

Nat Immunol. 15(2):195-204.

Description:

Many vaccines induce protective immunity via antibodies. Systems biology approaches have been used to determine signatures that can be used to predict vaccine-induced immunity in humans, but whether there is a 'universal signature' that can be used t...

File Type:

[PDF - 3.09 MB]
Comparative studies of infectivity, immunogenicity and cross-protective efficacy of live attenuated influenza vaccines containing nucleoprotein from cold-adapted or wild-type influenza virus in a mouse model

Personal Author:

Isakova-Sivak, Irina; Korenkov, Daniil; Smolonogina, Tatiana; Tretiak, Tatiana; Donina, Svetlana; Rekstin, Andrey; Naykhin, Anatoly; Shcherbik, Svetlana; Pearce, Nicholas; Chen, Li-Mei; Bousse, Tatiana; Rudenko, Larisa;

Published:

Nov 06 2016

Source:

Virology. 500:209-217.

Description:

This study sought to improve an existing live attenuated influenza vaccine (LAIV) by including nucleoprotein (NP) from wild-type virus rather than master donor virus (MDV). H7N9 LAIV reassortants with 6:2 (NP from MDV) and 5:3 (NP from wild-type viru...

File Type:

[PDF - 3.42 MB]
NADPH Oxidase 1 Is Associated with Altered Host Survival and T Cell Phenotypes after Influenza A Virus Infection in Mice

Personal Author:

Hofstetter, Amelia R.; De La Cruz, Juan A.; Cao, Weiping; Patel, Jenish; Belser, Jessica A.; McCoy, James; Liepkalns, Justine S.; Amoah, Samuel; Cheng, Guangjie; Ranjan, Priya; Diebold, Becky A.; Shieh, Wun-Ju; Zaki, Sherif; Katz, Jacqueline M.; Sambhara, Suryaprakash; Lambeth, J. David; Gangappa, Shivaprakash;

Published:

Feb 24 2016

Source:

PLoS One. 11(2).

Description:

The role of the reactive oxygen species-producing NADPH oxidase family of enzymes in the pathology of influenza A virus infection remains enigmatic. Previous reports implicated NADPH oxidase 2 in influenza A virus-induced inflammation. In contrast, N...

File Type:

[PDF - 3.14 MB]
Near-Infrared Laser Adjuvant for Influenza Vaccine

Personal Author:

Kashiwagi, Satoshi; Yuan, Jianping; Forbes, Benjamin; Hibert, Mathew L.; Lee, Eugene L. Q.; Whicher, Laura; Goudie, Calum; Yang, Yuan; Chen, Tao; Edelblute, Beth; Collette, Brian; Edington, Laurel; Trussler, James; Nezivar, Jean; Leblanc, Pierre; Bronson, Roderick; Tsukada, Kosuke; Suematsu, Makoto; Dover, Jeffrey; Brauns, Timothy; Gelfand, Jeffrey; Poznansky, Mark C.;

Published:

Dec 11 2013

Source:

PLoS One. 2013; 8(12).

Description:

Safe and effective immunologic adjuvants are often essential for vaccines. However, the choice of adjuvant for licensed vaccines is limited, especially for those that are administered intradermally. We show that non-tissue damaging, near-infrared (NI...

File Type:

[PDF - 6.37 MB]
Swine Influenza A Outbreak, Fort Dix, New Jersey, 1976

Personal Author:

Gaydos, Joel C.; Top, Franklin H.; Hodder, Richard A.; Russell, Philip K.;

Published:

Jan 2006

Source:

Emerg Infect Dis. 12(1):23-28.

Description:

In early 1976, the novel A/New Jersey/76 (Hsw1N1) influenza virus caused severe respiratory illness in 13 soldiers with 1 death at Fort Dix, New Jersey. Since A/New Jersey was similar to the 1918-1919 pandemic virus, rapid outbreak assessment and enh...

File Type:

[PDF - 97.75 KB]