Correlation between Human Leukocyte Antigen Class II Alleles and HAI Titers Detected Post-Influenza Vaccination

Moss, Alastair J.; Gaughran, Fiona P.; Karasu, Aliyye; Gilbert, Anthony S.; Mann, Alex J.; Gelder, Colin M.; Oxford, John S.; Stephens, Henry A.; Lambkin-Williams, Rob

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Correlation between Human Leukocyte Antigen Class II Alleles and HAI Titers Detected Post-Influenza Vaccination

Published Date:

Aug 09 2013

Source:

PLoS One. 2013; 8(8).

[PDF-82.05 KB]

Details:

Personal Authors:

Moss, Alastair J. ; Gaughran, Fiona P. ; Karasu, Aliyye ; Gilbert, Anthony S. ; Mann, Alex J. ; ... More ▼

Keywords:

[+]

Description:

Influenza is a major cause of morbidity and mortality. Despite vaccination, many elderly recipients do not develop a protective antibody response. To determine whether Human Leukocyte Antigen (HLA) alleles modulate seroprotection to influenza, a cohort of HLA class II-typed high-risk vaccine recipients was investigated. Haemagglutinin inhibition (HAI) titres were measured 14-40 days post-subunit vaccination. Seroprotection was defined as HAI titres reaching 40 or greater for all three vaccine strains. HLA-DRB1*04∶01 and HLA-DPB1*04∶01 alleles were detected at higher frequencies in seroprotected compared with non-seroprotected individuals. Thus, the presence of certain HLA class II alleles may determine the magnitude of antibody responses to influenza vaccination.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Supporting Files:

	license.txt	text/plain
	pone.0071376.nxml	text/plain
	pone.0071376.t001.gif	image/gif
	pone.0071376.t001.jpg	image/jpeg
	pone.0071376.t002.gif	image/gif
	pone.0071376.t002.jpg	image/jpeg
	pone.0071376.t003.gif	image/gif
	pone.0071376.t003.jpg	image/jpeg

No Related Documents.

You May Also Like:

Personalized Vaccinology: A Review

Personal Author:

Poland, GA; Ovsyannikova, IG; Kennedy, RB;

Published:

Jul 31 2017

Source:

Vaccine. 36(36):5350-5357.

Description:

At the current time, the field of vaccinology remains empirical in many respects. Vaccine development, vaccine immunogenicity, and vaccine efficacy have, for the most part, historically been driven by an empiric "isolate-inactivate-inject" paradigm. ...

Public Access
Available on:

August 28, 2019
Emerging Vaccine Informatics

Personal Author:

He, Yongqun; Rappuoli, Rino; De Groot, Anne S.; Chen, Robert T.;

Published:

Jun 15 2011

Source:

J Biomed Biotechnol. 2010; 2010.

Description:

Vaccine informatics is an emerging research area that focuses on development and applications of bioinformatics methods that can be used to facilitate every aspect of the preclinical, clinical, and postlicensure vaccine enterprises. Many immunoinform...

File Type:

[PDF - 930.92 KB]
Molecular signatures of antibody responses derived from a systems biological study of 5 human vaccines

Personal Author:

Li, Shuzhao; Rouphael, Nadine; Duraisingham, Sai; Romero-Steiner, Sandra; Presnell, Scott; Davis, Carl; Schmidt, Daniel S.; Johnson, Scott E.; Milton, Andrea; Rajam, Gowrisankar; Kasturi, Sudhir; Carlone, George M.; Quinn, Charlie; Chaussabel, Damien; Palucka, A. Karolina; Mulligan, Mark J.; Ahmed, Rafi; Stephens, David S.; Nakaya, Helder I; Pulendran, Bali;

Published:

Dec 15 2013

Source:

Nat Immunol. 15(2):195-204.

Description:

Many vaccines induce protective immunity via antibodies. Systems biology approaches have been used to determine signatures that can be used to predict vaccine-induced immunity in humans, but whether there is a 'universal signature' that can be used t...

File Type:

[PDF - 3.09 MB]
Arthropod-borne virus information exchange Number 37, September 1979

Personal Author:

Chamberlain, Roy W.

Corporate Author:

American Committee on Arthropod-Borne Viruses. Subcommittee on Information Exchange.. Center for Disease Control.

Published:

September 1979

Series:

Arthropod-borne virus information exchange ; no. 37

Description:

Something new has been added in this issue of the Information Exchange, namely, abstracts of arbovirus papers that will be presented at the 28th Annual Meeting of the American Society of Tropical Medicine and Hygiene, 14016 November, Tucson, Arizona....

File Type:

[PDF - 81.26 MB]
Comparative studies of infectivity, immunogenicity and cross-protective efficacy of live attenuated influenza vaccines containing nucleoprotein from cold-adapted or wild-type influenza virus in a mouse model

Personal Author:

Isakova-Sivak, Irina; Korenkov, Daniil; Smolonogina, Tatiana; Tretiak, Tatiana; Donina, Svetlana; Rekstin, Andrey; Naykhin, Anatoly; Shcherbik, Svetlana; Pearce, Nicholas; Chen, Li-Mei; Bousse, Tatiana; Rudenko, Larisa;

Published:

Nov 06 2016

Source:

Virology. 500:209-217.

Description:

This study sought to improve an existing live attenuated influenza vaccine (LAIV) by including nucleoprotein (NP) from wild-type virus rather than master donor virus (MDV). H7N9 LAIV reassortants with 6:2 (NP from MDV) and 5:3 (NP from wild-type viru...

File Type:

[PDF - 3.42 MB]