Impact of Work Task-Related Acute Occupational Smoke Exposures on Select Proinflammatory Immune Parameters in Wildland Firefighters

Details

• Personal Author:
  Adetona AM ; Adetona O ; Diaz-Sanchez D ; Gogal RM Jr. ; Naeher LP ; Rathbun SL
• Description:
  Objective: A repeated measures study was used to assess the effect of work tasks on select proinflammatory biomarkers in firefighters working at prescribed burns. Methods: Ten firefighters and two volunteers were monitored for particulate matter and carbon monoxide on workdays, January to July 2015. Before and after workshift dried blood spots were analyzed for inflammatory mediators using the Meso Scale Discovery assay, while blood smears were used to assess leukocyte parameters. Results: Firefighters lighting with drip-torches had higher cross-work-shift increases in interleukin-8, C-reactive protein, and serum amyloid A compared with holding, a task involving management of fire boundaries. A positive association between interleukin-8 and segmented-neutrophil was observed. Conclusion: Results from this study suggest that intermittent occupational diesel exposures contribute to cross-work-shift changes in host systemic innate inflammation as indicated by elevated interleukin-8 levels and peripheral blood segmented-neutrophils. [Description provided by NIOSH]
• Subjects:
  Biomarkers Blood Burns Carbon Monoxide Environmental Exposure Firefighters Fires Hematologic Tests Occupational Health Particulate Matter Risk Assessment Risk Factors Safety Vehicle Emissions Wildfires Workplace

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• Keywords:
  Blood Samples Carbon Monoxide Diesel Emissions Exposure Levels Fire Fighters Fire Fighting Leukocytes Monitoring Systems Neutrophils Particulates Proteins Risk Factors Smoke Inhalation Work Environment Workers

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• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; North Carolina ; Ohio ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  59
• Issue:
  7
• NIOSHTIC Number:
  nn:20050013
• Citation:
  J Occup Environ Med 2017 Jul; 59(7):679-690
• Contact Point Address:
  Luke P. Naeher, PhD, Department of Environmental Health Science, College of Public Health, University of Georgia, 206 Environmental Health Science Building, Athens, GA 30602-2102
• Email:
  LNaeher@uga.edu
• CAS Registry Number:
  Carbon monoxide (CAS RN 630-08-0)
• Federal Fiscal Year:
  2017
• Performing Organization:
  University of Alabama at Birmingham
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cc2976a984d3a4355b45fe4269578a1bc139346d6e31c8894e0bb118f010bf2bc8469b4ebe04e7e93d6ba87325947d80fd459c3ec1f9ebab078009bb6e840102
• Download URL:
  https://stacks.cdc.gov/view/cdc/210568/cdc_210568_DS1.pdf
• File Type:
  [PDF - 580.79 KB ]