Immediately Dangerous to Life or Health (IDLH) Value Profile: Acetonitrile [CAS No. 75-05-8] (Superseded)

Details

• Personal Author:
  Dotson, G. Scott ; Haber L ; Maier A ; Parker A
• Description:
  This document has been superseded and the new version can be found here. Overview of the IDLH Value for Acetonitrile IDLH value: 137 ppm (230 mg/m3). Basis for IDLH value: The mouse LC50 value of 2,693 ppm for a 60 minute exposure to acetonitrile [Willhite 1981] was selected as the basis for the IDLH value. Duration adjustment resulted in the calculation of a 30-minute equivalent LC50 value of 4,120 ppm. A composite uncertainty factor of 30 was applied to account for extrapolation from a concentration that is lethal to animals, animal to human differences, and human variability, resulting in an IDLH value for acetonitrile of 137 ppm. 1.2 Purpose: This IDLH Value Profile presents (1) a brief summary of technical data associated with acute inhalation exposures to acetonitrile and (2) the rationale behind the immediately dangerous to life or health (IDLH) value for acetonitrile. IDLH values are developed on the basis of scientific rationale and logic outlined in the NIOSH Current Intelligence Bulletin (CIB) 66: Derivation of Immediately Dangerous to Life or Health (IDLH) Values [NIOSH 2013]. As described in CIB 66, NIOSH performs in-depth literature searches to ensure that all relevant data from human and animal studies with acute exposures to the substance are identified. Information included in CIB 66 on the literature search includes pertinent databases, key terms, and guides for evaluating data quality and relevance for the establishment of an IDLH value. The information that is identified in the in-depth literature search is evaluated with general considerations that include description of studies (i.e., species, study protocol, exposure concentration and duration), health endpoint evaluated, and critical effect levels (e.g., NOAELs, LOAELs, and LC50 values). For acetonitrile, the in-depth literature search was conducted through July 2017. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Animals Chemistry Environmental Exposure Hazardous Substances Laboratories Lung Lung Diseases Morbidity Mortality Nitriles Occupational Health Pathology Respiratory System Respiratory Tract Diseases Safety

  More +
• Keywords:
  Acetonitrile Airborne Particles Chemical Hazards Chemical Properties Chemicals Chemical Safety Chemical Structure Chlorine Compounds Exposure Levels Fatalities Health Effects Humans IDLH Immediately Dangerous To Life Or Health Inhalation Kidneys Laboratory Animals LD50 Lethal Concentrations Liver Median Lethal Dose Morbidity Rates Mortality Data Organochlorine Compounds Organs Pulmonary System Pulmonary System Disorders Respiratory Irritants Respiratory System Disorders Spleen Disorders Systematic Reviews

  More +
• Series:
  NIOSH Numbered Publications
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-8
• NIOSHTIC Number:
  nn:20050453
• NTIS Accession Number:
  PB2018-100184
• Citation:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2017-203, 2017 Sep; :1-8
• CAS Registry Number:
  Chloroacetonitrile (CAS RN 107-14-2)
• Federal Fiscal Year:
  2017
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:667a632b531edff2bd3664330db2791ab8777ed783dc5af208a94d8a8d0d4ded41a89aa7e3e3c3228b05636bdaf695e252f1c320b445af6dc9a6614b0bca048c
• Download URL:
  https://stacks.cdc.gov/view/cdc/210094/cdc_210094_DS1.pdf
• File Type:
  [PDF - 386.50 KB ]