Current Intelligence Bulletin 6 – Hexamethylphosphoric Triamide (HMPA)

Details

• Personal Author:
  Lloyd JW
• Description:
  The National Institute for Occupational Safety and Health (NIOSH) has received a report from an American producer of hexamethylphosphoric triamide (HMPA), a synthetic organic chemical, indicating that malignant tumors have been produced in laboratory animals by exposure to HMPA. In light of the potential risk of human exposure to this chemical in the work environment, the National Institute for Occupational Safety and Health is advising the occupational health community of these findings. The occupational hazards presented by hexamethylphosphoric-triamide (680319), responsible for the induction of experimental nasal squamous cell carcinoma in rats, are reviewed briefly. It is estimated that 5,000 workers are occupationally exposed to the compound, most of them in research laboratories. There is no current OSHA standard for hexamethylphosphoric-triamide exposure. [Description provided by NIOSH]
• Subjects:
  Carcinogens Insecticides Neoplasms Nose Nose Diseases Occupational Health Organophosphates Respiratory Tract Diseases Safety Sense Organs Toxicology

  More +
• Keywords:
  Chemical-carcinogens Industrial-chemicals Nasal-cancer NIOSH-Author Organo-phosphorus-insecticides Respiratory-system-disorders Testing-facilities
• Series:
  NIOSH Numbered Publications
• Subseries:
  Current Intelligence Bulletin
• DOI:
  https://doi.org/10.26616/NIOSHPUB781276
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Handout/Flyer
• Place as Subject:
  Maryland ; Ohio ; OSHA Region 3 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OOHSB
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-8
• NIOSHTIC Number:
  nn:20022491
• Citation:
  Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 78-127, (CIB 6), 1975 Oct; :1-8
• CAS Registry Number:
  Hexamethylphosphoramide (CAS RN 680-31-9)
• Federal Fiscal Year:
  1976
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:311adaa504ade20b758f7f4a7f25c63cc7966f65b4899d58713f2864b7428342071e14dc969f43ab87aaa775071997b9c21902ea7f7f8369dfe5f3f04bca0d4d
• Download URL:
  https://stacks.cdc.gov/view/cdc/209841/cdc_209841_DS1.pdf
• File Type:
  [PDF - 674.82 KB ]