Current Intelligence Bulletin 29 – Glycidyl Ethers

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  The National Institute for Occupational Safety and Health (NIOSH) would like to inform the occupational health community of the possibility of adverse effects to the testes and the hemopoietic (blood forming) system in workers exposed to glycidyl ethers. During development of a NIOSH criteria document on glycidyl ethers, a pattern of research findings emerged which indicates that some of the glycidyl ethers may be capable of producing testicular atrophy and hemopoietic abnormalities in various species of laboratory animals. Additionally, after the issuance of the June 1978 NIOSH criteria document, a 1957 study was released to NIOSH reporting testicular atrophy in laboratory rats exposed to n-butyl glycidyl ether. While none of the individual research reports are conclusive with respect to the ability of glycidyl ethers to produce permanent changes to the testes or hemopoietic system in laboratory animals, some of the changes observed may act as predisposing factor to systemic problems. NIOSH is not aware of any studies investigating the possibility of occurrence of testicular atrophy or hemopoietic abnormalities occurring in humans exposed to glycidyl ethers. The possibility of these effects occurring in humans is reason for concern. Therefore, NIOSH requests that any information regarding testicular atrophy or hemopoietic abnormalities observed in workers exposed to glycidyl ethers be reported to the NIOSH Division of Surveillance, Hazard Evaluations, and Field Studies, Industry-Wide Studies Branch, Medical Section, Telephone: (513) 684-3593. NIOSH advises strict adherence to the detailed recommended occupational standard described in the glycidyl ethers criteria document. Particular attention should be given to appropriate medical surveillance in order to detect testicular atrophy or hemopoietic abnormalities in exposed workers. NIOSH requests that producers, distributors, users, professional associations, and unions transmit this information to their customers, employees, associates and members. [Description provided by NIOSH]
• Subjects:
  Chemistry Ether Hazardous Substances Occupational Health Safety
• Keywords:
  Chemical-properties Ethers Exposure-levels Hazardous-materials Industrial-medicine Occupational-safety-programs Toxicity
• Series:
  NIOSH Numbered Publications
• Subseries:
  Current Intelligence Bulletin
• DOI:
  https://doi.org/10.26616/NIOSHPUB79104
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Handout/Flyer
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DCDSD - Division of Criteria Documents and Standards Development
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-13
• NIOSHTIC Number:
  nn:20000302
• NTIS Accession Number:
  PB85-119154
• Citation:
  Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 79-104, (CIB 29), 1978 Oct; :1-13
• CAS Registry Number:
  2,2′-[Oxybis(methylene)]bis[oxirane] (CAS RN 2238-07-5) ; 2-[(1-Methylethoxy)methyl]oxirane (CAS RN 4016-14-2) ; Allyl glycidyl ether (CAS RN 106-92-3) ; Bisphenol A diglycidyl ether (CAS RN 1675-54-3) ; Butyl glycidyl ether (CAS RN 2426-08-6) ; Phenyl glycidyl ether (CAS RN 122-60-1) ; Resorcinol diglycidyl ether (CAS RN 101-90-6)
• Federal Fiscal Year:
  1979
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:11097cac73b370f1209dd321de8f47fe6ca861f0113aced73d1639632934c6732b163f414ec0bcee718c9e1f8fb3e9d2cebc4e407bcb8250363e39bcaf489b8e
• Download URL:
  https://stacks.cdc.gov/view/cdc/209784/cdc_209784_DS1.pdf
• File Type:
  [PDF - 948.24 KB ]