Current Intelligence Bulletin 28 – Vinyl Halides Carcinogenicity

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  The National Institute for Occupational Safety and Health (NIOSH) and the Occupational Safety and Health Administration (OSHA) jointly recommend that vinyl bromide and vinylidene chloride be considered in the workplace as potential carcinogens to humans and controlled with the same degree of prudence as vinyl chloride, another vinyl halide currently regulated as a carcinogen by OSHA. This recommendation is based on the results of recent studies indicating that exposure to vinyl bromide and to vinylidene chloride causes angiosarcoma of the liver and other cancers in laboratory animals. Safe levels of exposure to carcinogens have not been demonstrated, but lowered exposure to carcinogens may in general decrease the probability of cancer development. Vinyl chloride is known to cause angiosarcoma of the liver and cancers of other sites in laboratory animals and in humans. At this time, adequate carcinogenicity studies of vinyl bromide and vinylidene chloride have been conducted only in laboratory animals. In view of the present state of knowledge in carcinogenesis, substances that cause cancer in laboratory animals are considered a potential cancer risk to humans. Vinyl chloride is the only vinyl halide for which an OSHA exposure standard currently exists. In light of the recent laboratory animal studies demonstrating carcinogenicity of vinyl bromide and vinylidene chloride, NIOSH and OSHA have jointly prepared this Current Intelligence Bulletin. Its purpose is to advise the occupational health community of the pertinent data and complications for exposed workers. NIOSH and OSHA request that producers, distributors professional associations, and unions transmit the information in this Bulletin to their customers, employees, associates, and members. [Description provided by NIOSH]
• Subjects:
  Carcinogens Hazardous Substances Laboratories Mutagens Occupational Health Plastics Safety
• Keywords:
  Exposure-levels Hazardous-materials Laboratory-animals Occupational-safety-programs Plastics-industry Toxic-materials
• Series:
  NIOSH Numbered Publications
• Subseries:
  Current Intelligence Bulletin
• DOI:
  https://doi.org/10.26616/NIOSHPUB79102
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Handout/Flyer
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DCDSD - Division of Criteria Documents and Standards Development
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-12
• NIOSHTIC Number:
  nn:20000301
• NTIS Accession Number:
  PB85-119162
• Citation:
  Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 79-102, (CIB 28), 1978 Sep; :1-12
• CAS Registry Number:
  Bromoethene (CAS RN 593-60-2) ; Vinyl chloride (CAS RN 75-01-4) ; Vinylidene chloride (CAS RN 75-35-4)
• Federal Fiscal Year:
  1978
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:51a4b295896469c8a69c5f2e1ab4f9473acdae172c3f63a26d4221d46e5d79f6c88f8c5652bea0a7dc225be9ab03bcea857680152059d4aa9937974959ebdabd
• Download URL:
  https://stacks.cdc.gov/view/cdc/209783/cdc_209783_DS1.pdf
• File Type:
  [PDF - 3.85 MB ]