Current Intelligence Bulletin 46 – Methylene Chloride

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  B6C3F1 mice exposed to methylene chloride in air developed cancers (alveolar/bronchiolar carcinomas) and tumors (alveolar/bronchiolar adenomas) of the lung, and cancers (hepatocellular carcinomas) of the liver. Fischer 344/N rats exposed to methylene chloride in air developed tumors (fibromas and fibroadenomas) of the mammary gland. Sprague-Dawley rats exposed to methylene chloride in air developed cancers (sarcomas) of the salivary glands and tumors (fibromas and fibroadenomas) of the mammary glands. Though existing epidemiologic data derived from workers exposed to methylene chloride are inconclusive, the observation of cancers and tumors in both rats and mice treated with methylene chloride meets the criteria established in the Occupational Safety and Health Administration (OSHA) Cancer Policy for considering methylene chloride a "potential occupational carcinogen." Therefore, the National Institute for Occupational Safety and Health (NIOSH) recommends that worker exposure to methylene chloride be controlled to the lowest feasible limit. [Description provided by NIOSH]
• Subjects:
  Animals Carcinogens Epidemiology Neoplasms Occupational Health Safety
• Keywords:
  Animal-studies Cancer Carcinomas Tumors
• Series:
  NIOSH Numbered Publications
• Subseries:
  Current Intelligence Bulletin
• DOI:
  https://doi.org/10.26616/NIOSHPUB86114
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Handout/Flyer
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSDTT - Division of Standards Development and Technology Transfer
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-18
• NIOSHTIC Number:
  nn:20000243
• NTIS Accession Number:
  PB86-208303
• Citation:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 86-114, (CIB 46), 1986 Apr; :1-18
• Federal Fiscal Year:
  1986
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:dad8c3e63f24749fc1e7900c8addb123926467fa0332ef098e4a22757434c145db0ec5dfc442a734ee9f82fcde9063f4b61c4cd41d70588c58dbb01c6c457ba2
• Download URL:
  https://stacks.cdc.gov/view/cdc/209756/cdc_209756_DS1.pdf
• File Type:
  [PDF - 1.31 MB ]