Current Intelligence Bulletin 55 – Carcinogenicity of Acetaldehyde and Malonaldehyde, and Mutagenicity of Related Low-Molecular-Weight Aldehydes

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  A review of the data and a summary of findings regarding the potential carcinogenicity of acetaldehyde (75070) and malonaldehyde (542789) and the mutagenicity of related low molecular weight aldehydes were presented. Long term inhalation exposure of hamsters to acetaldehyde has produced laryngeal cancers and similar studies in rats have produced nasal cancers. Malonaldehyde produced adenomas and carcinomas of the thyroid gland and adenomas of the pancreatic islet cells during a long term gavage treatment of rats. Several assays have also shown that acetaldehyde and malonaldehyde have mutagenic properties. Adequate epidemiologic data were not available for workers exposed to acetaldehyde or malonaldehyde. Both chemicals meet the criteria of the OSHA to be considered potential carcinogens and NIOSH therefore recommends that worker exposures be reduced to the lowest feasible concentrations. The nine related aldehydes acrolein (107028), butryaldehyde (123728), crotonaldehyde (4170303), glutaraldehyde (111308), glyoxal (107222), paraformaldehyde (30525894), propionaldehyde (123386), propiolaldehyde (123386), and valeraldehyde (110623) are of concern because their chemical reactivities and mutagenic activities are similar to those of acetaldehyde and malonaldehyde and because they may be used as substitutes for formaldehyde. [Description provided by NIOSH]
• Subjects:
  Aldehydes Digestive System Digestive System Diseases Formaldehyde Laboratories Mutagens Neoplasms Nose Nose Diseases Occupational Exposure Occupational Health Safety Sense Organs

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• Keywords:
  Gastrointestinal-system-disorders Laboratory-animals Nasal-cancer NIOSH-Author NIOSH-Current-Intelligence-Bulletin-No-55 Occupational-exposure Pancreatic-islets-neoplasms
• Series:
  NIOSH Numbered Publications
• Subseries:
  Current Intelligence Bulletin
• DOI:
  https://doi.org/10.26616/NIOSHPUB91112
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Handout/Flyer
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSDTT - Division of Standards Development and Technology Transfer
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-50
• NIOSHTIC Number:
  nn:00202697
• NTIS Accession Number:
  PB92-131697
• Citation:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 91-112, (CIB 55), 1991 Sep; :1-50
• CAS Registry Number:
  Acetaldehyde (CAS RN 75-07-0) ; Acrolein (CAS RN 107-02-8) ; Butanal (CAS RN 123-72-8) ; Crotonaldehyde (CAS RN 4170-30-3) ; Glutaraldehyde (CAS RN 111-30-8) ; Glyoxal (CAS RN 107-22-2) ; Malonaldehyde (CAS RN 542-78-9) ; Paraformaldehyde (CAS RN 30525-89-4) ; Pentanal (CAS RN 110-62-3) ; Propanal (CAS RN 123-38-6)
• Federal Fiscal Year:
  1991
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f4193d60010ccccccf8e7c658f40162d4018b16297141c806562273c548f84fc50868d8e4eea91b3d47dc7b0562b651bb206d0195ac142fc1b3a4052aaafa940
• Download URL:
  https://stacks.cdc.gov/view/cdc/209623/cdc_209623_DS1.pdf
• File Type:
  [PDF - 1.38 MB ]