Special Occupational Hazard Review for Aldrin/Dieldrin

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  This review analyzed and documented, from a health standpoint, the problems associated with the use of aldrin (309002) and dieldrin (60571). In the United States, the production of these pesticides had been banned, although certain restricted uses were allowed. Studies have indicated that the estimated acute oral toxicity for humans is 65mg/kg. Animal studies indicated that both had considerable potential for carcinogenic effects in humans, having produced tumors in mice. Dieldrin caused significant increases in lung and liver tumors at dietary doses as low as 0.1 and 1 part per million, respectively. NIOSH recommends these two chemicals be handled in industry and the workplace as suspected occupational carcinogens, even though direct support evidence among humans is missing. Airborne concentrations of either chemical should not exceed 0.15mg/m3. Skin contact should be avoided as they can both be absorbed through the skin. When dissolved in organic solvents, this percutaneous absorption is greatly increased. Other aspects discussed in this review include the metabolism and pharmacokinetics, mode of action of general toxicity in animal studies, effects on central nervous system and peripheral motor effects among animals, reproductive effects in animals, and effects on humans in relation to clinical studies, case reports and epidemiological surveys. [Description provided by NIOSH]
• Subjects:
  Agriculture Carcinogens Chlorine Compounds Hazardous Substances Insecticides Laboratories Occupational Health Safety Teratogenesis
• Keywords:
  Agricultural-chemicals Agricultural-workers Chlorinated-hydrocarbon-pesticides Laboratory-animals NIOSH-Criteria-Document Organo-chlorine-compounds Teratogens Toxic-effects
• Series:
  NIOSH Numbered Publications
• DOI:
  https://doi.org/10.26616/NIOSHPUB78201
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Standards
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DCDSD - Division of Criteria Documents and Standards Development
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-175
• NIOSHTIC Number:
  nn:00184342
• NTIS Accession Number:
  PB-297769
• Citation:
  Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 78-201, 1978 Sep; :1-175
• CAS Registry Number:
  Aldrin (CAS RN 309-00-2) ; Dieldrin (CAS RN 60-57-1)
• Federal Fiscal Year:
  1978
• Performing Organization:
  JRB Associates, Inc.
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4373454b366a8724977196b14b34d0e004bad7e4bf7612b079987d10bac1d3cc7813049bf893d43b94e4fe821da0861d897542f3aa1fc749b377ced8abcd9b6f
• Download URL:
  https://stacks.cdc.gov/view/cdc/209554/cdc_209554_DS1.pdf
• File Type:
  [PDF - 4.82 MB ]