Current Intelligence Bulletin 18 – Acrylonitrile

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  The association between acrylonitrile (107131) exposure and excess incidences of lung and colon cancer were discussed. Physical and chemical properties of acrylonitrile and production use are summarized. NIOSH estimates that approximately 125,000 workers are potentially exposed to acrylonitrile. Epidemiologic and experimental studies found that occupational exposure to acrylonitrile may be associated with an excess of lung and colon cancer. Acute toxicity studies in laboratory animals indicated that inhalation of acrylonitrile caused damage to the central nervous system, lung, liver, and kidneys. When administered to pregnant mice, acrylonitrile was embryotoxic. Plans for the identification of a suitable worker population for possible epidemiologic studies are mentioned. NIOSH is currently conducting an evaluation of control technology in the plastics and resin industry (including acrylonitrile processes) and is developing a criteria document for acrylonitrile and other nitriles. The author recommends that acrylonitrile be treated in the workplace as a human carcinogen. Interim recommended industrial hygiene practices developed by NIOSH to help reduce occupational exposure to acrylonitrile are appended. [Description provided by NIOSH]
• Subjects:
  Carcinogens Chemistry Epidemiology Hazardous Substances Laboratories Nitrogen Compounds Occupational Exposure Occupational Health Personal Protective Equipment Risk Assessment Safety

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• Keywords:
  Carcinogenesis Chemical-properties Health-hazards In-vivo-studies Laboratory-animals NIOSH-Author NIOSH-Current-Intelligence-Bulletin-No-18 Occupational-exposure Organo-nitrogen-compounds Physical-properties Protective-measures Risk-analysis

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• Series:
  NIOSH Numbered Publications
• Subseries:
  Current Intelligence Bulletin
• DOI:
  https://doi.org/10.26616/NIOSHPUB7812718
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Handout/Flyer
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DCDSD - Division of Criteria Documents and Standards Development
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-6
• NIOSHTIC Number:
  nn:00170799
• NTIS Accession Number:
  PB83-105080
• Citation:
  Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 78-127, (CIB 18), 1977 Jul; :1-6
• CAS Registry Number:
  Acrylonitrile (CAS RN 107-13-1)
• Federal Fiscal Year:
  1977
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0de7184ef8a454e93ce65af344f4616fe5ef33e713323f52a0658a7abca0141ddbcd952967b3bb648c3a4692d39e32e129acbed072f9ca28aba721e751cf267b
• Download URL:
  https://stacks.cdc.gov/view/cdc/209493/cdc_209493_DS1.pdf
• File Type:
  [PDF - 814.74 KB ]